Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15521
Tipo do documento: Artigo
Título: Lack of association between IL-10 -1082G/A polymorphism and chronic periodontal disease in adults
Autor: Hannum, Renato
Godoy, Fernanda Ribeiro
Cruz, Alex Silva da
Vieira, Thaís Cidália
Minasi, Lysa Bernardes
Silva, Daniela de Melo e
Silva, Cláudio Carlos da
Cruz, Aparecido Divino da
Abstract: Because of the complex interaction between periodontal pathogens and the host defense system, periodontitis is considered an inflammatory disorder of bacterial etiology that results in periodontal tissue damage. Genetic mechanisms may interfere with the gene expression of important inflammation mediators, modulating the immunologic response of an individual. In this study, we evaluated the single nucleotide polymorphism -1082G/A in the promoter region of interleukin-10 gene and its relationship with periodontal disease in Central Brazil. We included 36 cases classified according to disease severity (mild, moderate, or severe) and 30 controls. The allelic distribution of the cases was 16 (44%) AG, followed by 13 (36%) GG and 7 (20%) with the genotype AA. In the control group, 13 (43%) presented the genotype AG, 12 (40%) GG and 5 (17%) were classified as AA. The populations examined were in Hardy-Weinberg equilibrium. Analysis of allelic and genotypic frequencies revealed no casual relationship with the presence of genotype G or A and the development of periodontal disease in adults. The single nucleotide polymorphism -1082G/A of the interleukin-10 gene was not predictive of periodontal disease.
Palavras-chave: Inflammation
Interleukin-10
Periodontal disease
Polymorphism
País: Brasil
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: HANNUM, R.; GODOY, F. R.; CRUZ, A. S. da; VIEIRA, T. C.; MINASI, L. B.; SILVA, D. de M. e ; SILVA, C. C. da; CRUZ, A. D. da. Lack of association between IL-10 -1082G/A polymorphism and chronic periodontal disease in adults. Genetics and Molecular Research, Ribeirão Preto, v. 14, n. 4, p. 17828-17833, Dec. 2015.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.4238/2015.December.22.7
e- 1676-5680
Identificador do documento: 10.4238/2015.December.22.7
e- 1676-5680
URI: http://repositorio.bc.ufg.br/handle/ri/15521
Data de publicação: Dez-2015
Aparece nas coleções:ICB - Artigos publicados em periódicos

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