Cytogenetic damage in the buccal epithelium of Brazilian aviators occupationally exposed to agrochemicals
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2010-12
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Resumo
The frequency of micronuclei in both buccal cells and peripheral blood lymphocytes is extensively used as a biomarker of chromosomal damage and genome stability in human populations. We examined whether prolonged exposure to complex mixtures of pesticides leads to an increase in cytogenetic damage. The exposed
group comprised 50 agricultural aviators, mainly from Central and
Southeast regions of Brazil, who had inhaled agrochemicals for more
than 10 years without personal protection equipment; the control group
consisted of 17 men from the same regions, without indication of
exposure to pesticides, There were three times higher frequencies of
micronuclei (P < 0.05) and 2.5 times higher frequencies of binucleated
cells in the aviators when compared to controls. However, cytotoxic
alterations such as broken eggs and karyorrhexis did not present
statistically significant differences between the exposed and control
groups. Therefore, diverse agrochemicals used to combat pests
in agriculture possess genotoxic effects in the oral mucosa of the
agricultural pilots, as showed in this study.
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Genotoxic agents, Mutagenesis, Biomonitoring, Occupational exposure
Citação
MINASI, L. B.; COSTA, E .O. A.; SILVA, D. M.; MELO, C. O. A.; ALMEIDA, J. G. de; VIEIRA, T. C.; SILVA JÚNIOR, R. L.; RIBEIRO, C. L.; SILVA, C. C. da; CRUZ, A. D. da. Cytogenetic damage in the buccal epithelium of Brazilian aviators occupationally exposed to agrochemicals. Genetics and Molecular Research, Ribeirão Preto, v. 10, n. 4, p. 1-6, Dec. 2011.