Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15565
Tipo do documento: Artigo
Título: In vitro susceptility characteristics of Cryptococcus varieties from AIDS patients in Goiânia, Brazil
Autor: Fernandes, Orionalda Fatima Lisboa
Passos, Xisto Sena
Souza, Lúcia Kioko Hasimoto e
Miranda, André T. B.
Cerqueira, Carlos Henrique Pacini Vieira de
Silva, Maria do Rosário Rodrigues
Abstract: Sixty clinical isolates of Cryptococcus neoformans from AIDS from Goiânia, state of Goiás, Brazil, were characterized according to varieties, serotypes and tested for antifungal susceptibility. To differentiate the two varieties was used L-canavanine-glycine-bromothymol blue medium and to separate the serotypes was used slide agglutination test with Crypto Check Iatron. The Minimal Inhibitory Concentration (MIC) of fluconazole, itraconazole, and amphotericin B were determined by the National Committee for Clinical Laboratory Standards macrodilution method. Our results identified 56 isolates as C. neoformans var. neoformans serotype A and 4 isolates as C. neoformans var. gattii serotype B. MIC values for C. neoformans var. gattii were higher than C. neoformans var. neoformans. We verified that none isolate was resistant to itraconazole and to amphotericin B, but one C. neoformans var. neoformans and three C. neoformans var. gattii isolates were resistant to fluconazole. The presence of C. neoformans var. gattii fluconazole resistant indicates the importance of determining not only the variety of C. neoformans infecting the patients but also measuring the MIC of the isolate in order to properly orient treatment.
Palavras-chave: Serotypes
Brazil
Antifungal susceptibility
Goiânia
Cryptococcus neoformans
País: Brasil
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: FERNANDES, Orionalda de F. L.; PASSOS, Xisto S.; SOUZA, Lúcia K. H.; MIRANDA, André T. B.; CERQUEIRA, Carlos Henrique P. V.; SILVA, Maria do Rosário R. In vitro susceptility characteristics of Cryptococcus varieties from AIDS patients in Goiânia, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, Brasil, v. 98, n. 6, p. 839-841, Sept. 2003.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1590/S0074-02762003000600022
Identificador do documento: 10.1590/S0074-02762003000600022
URI: http://repositorio.bc.ufg.br/handle/ri/15565
Data de publicação: Set-2003
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
Artigo - Orionalda Fatima Lisboa Fernandes - 2003.pdf514,86 kBAdobe PDFThumbnail
Baixar/Abrir


Este item está licenciada sob uma Licença Creative Commons Creative Commons