In vitro susceptility characteristics of Cryptococcus varieties from AIDS patients in Goiânia, Brazil
Carregando...
Data
2003-09
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Sixty clinical isolates of Cryptococcus neoformans from AIDS from Goiânia, state of Goiás, Brazil, were
characterized according to varieties, serotypes and tested for antifungal susceptibility. To differentiate the two
varieties was used L-canavanine-glycine-bromothymol blue medium and to separate the serotypes was used slide
agglutination test with Crypto Check Iatron. The Minimal Inhibitory Concentration (MIC) of fluconazole,
itraconazole, and amphotericin B were determined by the National Committee for Clinical Laboratory Standards
macrodilution method. Our results identified 56 isolates as C. neoformans var. neoformans serotype A and 4 isolates
as C. neoformans var. gattii serotype B. MIC values for C. neoformans var. gattii were higher than C. neoformans var.
neoformans. We verified that none isolate was resistant to itraconazole and to amphotericin B, but one C. neoformans
var. neoformans and three C. neoformans var. gattii isolates were resistant to fluconazole. The presence of C.
neoformans var. gattii fluconazole resistant indicates the importance of determining not only the variety of C.
neoformans infecting the patients but also measuring the MIC of the isolate in order to properly orient treatment.
Descrição
Palavras-chave
Serotypes, Brazil, Antifungal susceptibility, Goiânia, Cryptococcus neoformans
Citação
FERNANDES, Orionalda de F. L.; PASSOS, Xisto S.; SOUZA, Lúcia K. H.; MIRANDA, André T. B.; CERQUEIRA, Carlos Henrique P. V.; SILVA, Maria do Rosário R. In vitro susceptility characteristics of Cryptococcus varieties from AIDS patients in Goiânia, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, Brasil, v. 98, n. 6, p. 839-841, Sept. 2003.