Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15570
Tipo do documento: Artigo
Título: Analysis of spleen cells in susceptible and resistant mice with experimental lagochilascariosis
Autor: Lara, Priscila Guirão
Prudente, Mariana Félix de Souza
Dias, Neusa Mariana Costa
Tambourgi, Denise Vilarinho
Lino Junior, Ruy de Souza
Ferreira, Mônica Spadafora
Carvalhaes, Mara Silvia
Abstract: Lagochilascariosis is an emerging parasitic disease caused by the helminth Lagochilascaris minor. e experimental mouse model has been used to study the immune response against L. minor infection. In the present work, immunohistochemistry analysis of spleen cells populations was evaluated in susceptible (C57BL/6) and resistant (BALB/c) mice experimentally infected with L. minor. e BALB/c mice exhibited increased spleen cell indexes as follows: F4/80+ at 100 days aer infection (DPI), CD4+ at 100 and 250 DPI, CD8+ at 35 and 100 DPI, and CD19+ at 100, 150, and 250 DPI. In the spleens of the infected C57BL/6 mice, increased indexes of the following spleen cells were observed: F4/80+ cells at 250 DPI, CD4+ cells at 150 DPI, CD8+ cells at 35, 150, and 250 DPI, and CD19+ cells at 150 to 250 DPI. e index of spleen cells con�rmed the differences between the control and infected groups at several time points following the infection. ese data demonstrate an association between a preferential increase in the number of CD4+ and CD19+ spleen cells and resistance to experimental lagochilascariosis in BALB/c mice and between a preferential increase in the number of CD8+ spleen cells and susceptibility in C57BL/6 mice.
País: Gra-bretanha
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: LARA, Priscila Guirão; PRUDENTE, Mariana Felix de Souza; DIAS, Neusa Mariana Costa; TAMBOURGI, Denise Vilarinho; LINO-JUNIOR, Ruy de Souza; SPADAFORA-FERREIRA, Mônica; CARVALHAES, Mara Silvia. Analysis of spleen cells in susceptible and resistant mice with experimental lagochilascariosis. ISRN Parasitology, London, v. 2013, p. 1-8, 2013.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.5402/2013/180652
Identificador do documento: 10.5402/2013/180652
URI: http://repositorio.bc.ufg.br/handle/ri/15570
Data de publicação: 2013
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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