The effect of carbon dioxide therapy on composite graft survival
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Data
2013-08
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Resumo
PURPOSE: To investigate the effect of carboxytherapy in auricular composite grafts in rabbits.
METHODS: An experimental study was conducted using 20 rabbits randomly assigned to a treatment group of carboxytherapy or a
control group of saline solution. In each ear, a circular graft with 1.5 cm or 2 cm of diameter was amputated and reattached. Animals
underwent carbon dioxide or saline injection four times during the experiment. We analyzed clinical evolution of the animals, grafts
survival, histopathology features and histomorphometry of collagen.
RESULTS: The treated group had a significantly lower weight gain (p=0.038). Histopathology was not significantly different between
groups. There was an increase in amount of collagen in 2 cm grafts submitted to carbon dioxide therapy (p=0.003). Carboxytherapy
didn’t influence graft survival rate for 1.5 cm grafts or 2 cm grafts (p=0.567 and p=0.777, respectively).
CONCLUSIONS: Carbon dioxide therapy increased the amount of collagen in 2 cm grafts. CO 2 was not significantly different from
saline infusion on composite grafts survival, but this study suggests that there is a mechanical effect caused by distension which favored
graft survival.
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Wound healing, Rabbits, Graft survival, Carbon dioxide
Citação
DURÃES, Eliana Ferreira Ribeiro; DURÃES, Leonardo de Castro; CARNEIRO, Fabiana Pirani; LINO JÚNIOR, Ruy de Souza; SOUSA, João Batista de. The effect of carbon dioxide therapy on composite graft survival. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 8, p. 589-593, Aug. 2013.