Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15581
Tipo do documento: Artigo
Título: Sleep deprivation alters rat ventral prostate morphology, leading to glandular atrophy: a microscopic study contrasted with the hormonal assays
Autor: Venâncio, Daniel Paulino
Andersen, Monica Levy
Vilamaior, Patricia Simone Leite
Santos, Fernanda Cristina Alcantara dos
Zager, Adriano
Tufik, Sérgio
Taboga, Sebastião Roberto
Mello, Marco Túlio
Abstract: We investigated the effect of 96 h paradoxical sleep deprivation (PSD) and 21-day sleep restriction (SR) on prostate morphology using stereological assays in male rats. After euthanasia, the rat ventral prostate was removed, weighed, and prepared for conventional light microscopy.Microscopic analysis of the prostate reveals that morphology of this gland was altered after 96 h of PSD and 21 days of SR, with the most important alterations occurring in the epithelium and stroma in the course of both procedures compared with the control group. Both 96 h PSD and 21-day SR rats showed lower serum testosterone and higher corticosterone levels than control rats. The significance of our result referring to the sleep deprivation was responsible for deep morphological alterations in ventral prostate tissue, like to castration microscopic modifications. This result is due to the marked alterations in hormonal status caused by PSD and SR.
País: Gra-bretanha
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: VENÂNCIO, Daniel P.; ANDERSEN, Monica L.; VILAMAIOR, Patrícia S. L.; SANTOS, Fernanda C.; ZAGER, Adriano; TUFIK, Sérgio; TABOGA, Sebastião R.; MELLO, Marco T. de. Sleep deprivation alters rat ventral prostate morphology, leading to glandular atrophy: a microscopic study contrasted with the hormonal assays. Journal of Biomedicine and Biotechnology, London, v. 2012, e285938, 2012.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1155/2012/285938
Identificador do documento: 10.1155/2012/285938
URI: http://repositorio.bc.ufg.br/handle/ri/15581
Data de publicação: 2012
Aparece nas coleções:ICB - Artigos publicados em periódicos

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