Sleep deprivation alters rat ventral prostate morphology, leading to glandular atrophy: a microscopic study contrasted with the hormonal assays
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2012
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We investigated the effect of 96 h paradoxical sleep deprivation (PSD) and 21-day sleep restriction (SR) on prostate morphology
using stereological assays in male rats. After euthanasia, the rat ventral prostate was removed, weighed, and prepared for conventional
light microscopy.Microscopic analysis of the prostate reveals that morphology of this gland was altered after 96 h of PSD
and 21 days of SR, with the most important alterations occurring in the epithelium and stroma in the course of both procedures
compared with the control group. Both 96 h PSD and 21-day SR rats showed lower serum testosterone and higher corticosterone
levels than control rats. The significance of our result referring to the sleep deprivation was responsible for deep morphological
alterations in ventral prostate tissue, like to castration microscopic modifications. This result is due to the marked alterations in
hormonal status caused by PSD and SR.
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VENÂNCIO, Daniel P.; ANDERSEN, Monica L.; VILAMAIOR, Patrícia S. L.; SANTOS, Fernanda C.; ZAGER, Adriano; TUFIK, Sérgio; TABOGA, Sebastião R.; MELLO, Marco T. de. Sleep deprivation alters rat ventral prostate morphology, leading to glandular atrophy: a microscopic study contrasted with the hormonal assays. Journal of Biomedicine and Biotechnology, London, v. 2012, e285938, 2012.