Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15585
Tipo do documento: Artigo
Título: The effect of carbon dioxide pneumoperitoneum on the healing colonic anastomosis in rats
Autor: Durães, Leonardo de Castro
Farias, Igor Eduardo Caetano de
Morais, Pedro Henrique Alves de
Oliveira, Paulo Gonçalves de
Cavalcanti Neto, Florêncio Figueiredo
Lino Junior, Ruy de Souza
Feres, Omar
Sousa, João Batista de
Abstract: PURPOSE: To investigate the effects of pneumoperitoneum on colonic anastomosis healing. METHODS: Colonic anastomosis was performed in 120 rats divided into four groups: Group I - pneumoperitoneum before laparotomy, Group II - pneumoperitoneum after laparorrhaphy, Group III - pneumoperitoneum before laparotomy and after laparorrhaphy, Group IV – no pneumoperitoneum (control group). Pneumoperitoneum pressure was 5 mmHg. Animals were killed on the 3 rd , 7 th and 14 th postoperative day. Hhistopathological features, anastomosis breaking strength, collagen histomorphometry and hydroxyproline concentration were assessed. RESULTS: Breaking strength between groups: (day 3, p = 0.165; day 7, p = 0.219; day 14, p = 0.539). Histopathology revealed that group II had, on day 7, less infiltration of mononuclear cells (p = 0.006), greater infiltration of polymorphonuclear cells (p = 0.001) and greater necrosis (p = 0.001); and on day 14, less fibrosis. Histomorphometry revealed a decrease in collagen in groups I and III (p < 0.001) on day 7 and an increase in groups I and II on day 14 (p < 0.001). Hydroxyproline concentration was similar for groups on days 3 (p = 0.152), 7 (p = 0.913) or 14 (p = 0.981). CONCLUSION: Carbon dioxide does not impair the healing of colonic anastomosis in rats.
Palavras-chave: Pneumoperitoneum
Colon
Rats
Artificial
Carbon dioxide
Surgical
Anastomosis
Wound healing
País: Brasil
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: DURÃES, Leonardo de Castro; FARIAS, Igor Eduardo Caetano de; MORAIS, Pedro Henrique Alves de; OLIVEIRA, Paulo Gonçalves de; CAVALCANTI NETO, Florêncio Figueiredo; LINO JÚNIOR, Ruy de Souza; FERES, Omar; SOUSA, João Batista de. The effect of carbon dioxide pneumoperitoneum on the healing colonic anastomosis in rats. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 9, p. 670-677, 2013.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1590/S0102-86502013000900008
Identificador do documento: 10.1590/S0102-86502013000900008
URI: http://repositorio.bc.ufg.br/handle/ri/15585
Data de publicação: 2013
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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