Análise das subpopulações de monócitos em pacientes HIV-1 positivos em uso ou não de antirretrovirais
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2015
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Resumo
Introduction: monocytes may be divided into subsets based
on the levels of CD14 and CD16 expression: classical
(CD14highCD16-), intermediate (CD14highCD16+) and
non-classical (CD14lowCD16+). Objective: to evaluate the
monocyte subsets in patients infected with HIV-1 in use or
not of Antiretroviral Therapy (ART). Methods: we analyzed four
study groups, made up of: individuals not infected with HIV-
1; individuals infected with HIV-1 without the use of ART; individuals infected with HIV-1 whose ART
consisted of two Reverse Transcriptase Inhibitors
Nucleoside (T1) and individuals infected with
HIV-1 whose ART consisted of two Reverse
Transcriptase Nucleoside Inhibitors associated
with one Reverse Transcriptase not Nucleoside
Inhibitor (T2 ). Monocyte subsets were determined
by flow cytometry and the statistical analyzes
performed with the GraphPad Prism 6. Results: the
CD14highCD16 subset presented low percentage
in T1 and T2. In CD14lowCD16+ subset, as well
as reduced in the mentioned groups, there was
also a reduction in the patients who did not use
ART. In CD14highCD16- monocytes, we see a
low percentage of the control group. Conclusion:
monocytes are also important targets of ART,
contributing to the control of HIV-1 infection,
since they act as a reservoir and virus spreading
through the tissues.
Descrição
Palavras-chave
Subpopulação de monócitos, HIV-1, Terapia antirretroviral, Inibidores da transcriptase reversa, Monocyte subsets, Antiretroviral therapy (ART), HIV-1, Reverse transcriptase inhibitors
Citação
CARVALHO, Amandda Évelin Silva de; MORAIS, Camila Oliveira Barbosa de; PFRIMER, Irmtraut Araci Hoffmann; FONSECA, Simone Gonçalve. Análise das subpopulações de monócitos em pacientes HIV-1 positivos em uso ou não de antirretrovirais. Revista Panamericana de Infectología, Ciudad Panama, v. 17, n. 3, p. 132-138, 2015.