Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15616
Tipo do documento: Artigo
Título: Crotalus durissus collilineatus venom induces tnf-α and il-10 production in human peripheral blood mononuclear cells
Autor: Ribeiro, Camila Bastos
Santos, Jéssica Cristina dos
Silva, Jacyelle Medeiros
Godoi, Pedro Henrique Silva de
Magalhães, Marta Regina
Ferreira, Mônica Spadafora
Fonseca, Simone Gonçalves
Pfrimer, Irmtraut Araci Hoffmann
Abstract: Snake venom has been the subject of numerous studies in an attempt to find properties and biological effects that may be beneficial to man. In this study we evaluated in vitro the effects of Crotalus durissus terrificus (Cdt) and Crotalus durissus collilineatus (Cdc) venom in human peripheral blood mononuclear cells (PBMCs). At 24 h, a significant decrease of viable cells was observed in cells stimulated with the Cdc venom at 0.0005 mg/mL and 0.005 mg/mL compared to the negative control. At 48 h, a significant decrease of viable cells was observed only in cells stimulated with Cdc venom at 0.005 mg/mL. A significant increase of TNF-α and IL-10 was detected 48 hours after culture of PBMC with Cdc, but not with Cdt venom. The expression of CD69 and PD1 (programmed death- 1), activation and regulatory cell markers, on CD8+ and CD8− T cells did not change in the presence of Cdt and Cdc venom. Our results suggest the presence of proinflammatory and anti-inflammatory components in the Cdc venom. Further analysis should be done to identify those Cdc venom components as it has been done for the Cdt venom by other authors, indicating that modulatory components are found in the venom of different species of Crotalus snakes.
País: Estados unidos
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: RIBEIRO, Camila Bastos; SANTOS, Jéssica Cristina dos; SILVA, Jacyelle Medeiros; GODOI, Pedro Henrique Silva de; MAGALHÃES, Marta Regina; SPADAFORA-FERREIRA, Mônica; FONSECA, Simone Gonçalves; FRIMER, Iirmtraut Araci Hoffman. Crotalus durissus collilineatus venom induces tnf-α and il-10 production in human peripheral blood mononuclear cells. ISRN Inflammation, Rockville, v. 2014, p. 1-7, 2014.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1155/2014/563628
Identificador do documento: 10.1155/2014/563628
URI: http://repositorio.bc.ufg.br/handle/ri/15616
Data de publicação: 2014
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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