Selection of filamentous fungi of the Beauveria genus able to metabolize quercetin like mammalian cells
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Data
2008
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Resumo
Microbial biotransformations constitute an important alternative as models for drug metabolism study in
mammalians and have been used for the industrial synthesis of chemicals with pharmaceutical purposes.
Several microorganisms with unique biotransformation ability have been found by intensive screening and
put in commercial applications. Ten isolates of Beauveria sp genus filamentous fungi, isolated from soil in the
central Brazil, and Beauveria bassiana ATCC 7159 were evaluated for their capability of quercetin
biotransformation. Biotransformation processes were carried out for 24 up to 96 hours and monitored by mass
spectrometry analyses of the culture broth. All strains were able to metabolize quercetin, forming mammalian
metabolites. The results were different from those presented by other microorganisms previously utilized,
attrackting attention because of the great diversity of reactions. Methylated, sulphated, monoglucuronidated,
and glucuronidated conjugated metabolites were simultaneously detected.
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Beauveria bassiana, Biotransformation, Quercetin, Beauveria bassiana, Biotransformação, Quercetina
Citação
COSTA, Eula Maria de M. B.; Pimenta, Fabiana Cristina; LUZ, Wolf Christian; OLIVEIRA, Valéria de.Selection of filamentous fungi of the Beauveria genus able to metabolize quercetin like mammalian cells. Brazilian Journal of Microbiology, São Paulo, v. 39, n. 2, p. 405-408, 2008.