Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15677
Tipo do documento: Artigo
Título: Increased expression of angiotensin II type 2 receptors in the solitary-vagal complex blunts renovascular hypertension
Autor: Blanch, Graziela Torres
Oliveira, André Henrique Freiria de
Speretta, Guilherme Fleury Fina
Carrera, Eduardo J.
Hongwei, Li
Speth, Robert C.
Colombari, Eduardo
Sumners, Colin
Colombari, Débora Simões de Almeida
Abstract: Angiotensin II increases and decreases arterial pressure by acting at angiotensin type 1 and type 2 receptors, respectively. Renovascular hypertensive rats exhibit a high level of activity of the peripheral and central renin–angiotensin system. Therefore, in the present study, we evaluated the effect of increasing the expression of angiotensin type 2 receptors in the solitary–vagal complex (nucleus of the solitary tract/dorsal motor nucleus of the vagus), a key brain stem region for cardiovascular regulation, on the development of renovascular hypertension. Holtzman normotensive rats were implanted with a silver clip around the left renal artery to induce 2-kidney 1-clip renovascular hypertension. Three weeks later, rats were microinjected in the solitary–vagal complex with either an adenoassociated virus to increase the expression of angiotensin type 2 receptors or with a control vector. We observed that increasing angiotensin type 2 receptor expression in the solitary–vagal complex attenuated the development of renovascular hypertension and also reversed the impairment of the baroreflex and the increase in the low-frequency component of systolic blood pressure observed in renovascular hypertensive rats. Furthermore, an observed decrease in mRNA levels of angiotensin-converting enzyme 2 in the solitary–vagal complex of renovascular hypertensive rats was restored to control levels after viral-mediated increases in angiotensin type 2 receptors at this site. Collectively, these data demonstrate specific and beneficial effects of angiotensin type 2 receptors via the brain of hypertensive rats and suggest that central angiotensin type 2 receptors may be a potential target for therapeutics in renovascular hypertension.
Palavras-chave: Angiotensin II
Angiotensin-converting enzyme 2
Angiotensin receptor blockers
Baroreflex
País: Estados unidos
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: BLANCH, Graziela Torres; FREIRIA-OLIVEIRA, André Henrique; SPERETTA, Guilherme Fleury Fina; CARREIRA, Eduardo J.; HONGWEI, Li; SPETH, Robert C.; COLOMBARI, Eduardo; SUMNERS, Colin; COLOMBARI, Débora S. A. Increased expression of angiotensin ii type 2 receptors in the solitary-vagal complex blunts renovascular hypertension. Hypertension, Dallas, v. 64, p. 777-783, Oct. 2014.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1161/HYPERTENSIONAHA.114.03188
Identificador do documento: 10.1161/HYPERTENSIONAHA.114.03188
URI: http://repositorio.bc.ufg.br/handle/ri/15677
Data de publicação: Out-2014
Aparece nas coleções:ICB - Artigos publicados em periódicos

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