Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15678
Tipo do documento: Artigo
Título: Median preoptic nucleus mediates the cardiovascular recovery induced by hypertonic saline in hemorrhagic shock
Autor: Amaral, Nathalia Oda
Naves, Lara Marques
Ferreira-Neto, Marcos Luiz
Oliveira, André Henrique Freiria de
Colombari, Eduardo
Rosa, Daniel Alves
Reis, Angela Adamski da Silva
Ianzer, Danielle Alves
Custódio, Carlos Henrique Xavier
Pedrino, Gustavo Rodrigues
Abstract: Changes in plasma osmolarity, through central and peripheral osmoreceptors, activate the median preoptic nucleus (MnPO) that modulates autonomic and neuroendocrine adjustments. The present study sought to determine the participation of MnPO in the cardiovascular recovery induced by hypertonic saline infusion (HSI) in rats submitted to hemorrhagic shock. The recordings of mean arterial pressure (MAP) and renal vascular conductance (RVC) were carried out on male Wistar rats (250–300 g). Hemorrhagic shock was induced by blood withdrawal over 20 min until the MAP values of approximately 60 mmHg were attained. The nanoinjection (100 nL) of GABA A agonist (Muscimol 4 mM; experimental group (EXP)) or isotonic saline (NaCl 150 mM; control (CONT)) into MnPO was performed 2 min prior to intravenous overload of sodium through HSI (3 M NaCl, 1.8 mL/kg, b.wt.). Hemorrhagic shock reduced the MAP in control (62 ± 1.1 mmHg) and EXP (61 ± 0.4 mmHg) equipotently. The inhibition of MnPO impaired MAP (CONT: 104 ± 4.2 versus EXP: 60 ± 6.2 mmHg) and RVC (CONT: 6.4 ± 11.4 versus EXP: −53.5 ± 10.0) recovery 10 min after HSI. The overall results in this study demonstrated, for the first time, that the MnPO plays an essential role in the HSI induced resuscitation during hypovolemic hemorrhagic shock.
País: Gra-bretanha
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: AMARAL, Nathalia Oda; NAVES, Lara Marques; FERREIRA-NETO, Marcos Luiz; FREIRIA-OLIVEIRA, André Henrique; COLOMBARI, Eduardo; ROSA, Daniel Alves; REIS, Angela Adamski da Silva; IANZER, Danielle; XAVIER, Carlos Henrique; PEDRINO, Gustavo Rodrigues. Median preoptic nucleus mediates the cardiovascular recovery induced by hypertonic saline in hemorrhagic shock. The Scientific World Journal, London, v. 2014, p. 1-9, 2014.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1155/2014/496121
Identificador do documento: 10.1155/2014/496121
URI: http://repositorio.bc.ufg.br/handle/ri/15678
Data de publicação: 2014
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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