New cardiovascular and pulmonary therapeutic strategies based on the angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis.
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2012
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Angiotensin (Ang)-(1–7) is now recognized as a biologically active component of the renin-angiotensin system (RAS). The
discovery of the angiotensin-converting enzyme homologue ACE2 revealed important metabolic pathways involved in the Ang-
(1–7) synthesis. This enzyme can form Ang-(1–7) from Ang II or less efficiently through hydrolysis of Ang I to Ang-(1–9) with
subsequent Ang-(1–7) formation. Additionally, it is well established that the G protein-coupled receptor Mas is a functional ligand
site for Ang-(1–7). The axis formed by ACE2/Ang-(1–7)/Mas represents an endogenous counter regulatory pathway within the
RAS whose actions are opposite to the vasoconstrictor/proliferative arm of the RAS constituted by ACE/Ang II/AT 1 receptor. In
this review we will discuss recent findings concerning the biological role of the ACE2/Ang-(1–7)/Mas arm in the cardiovascular
and pulmonary system. Also, we will highlight the initiatives to develop potential therapeutic strategies based on this axis.
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FERREIRA, Anderson J.; MURÇA, Tatiane M.; FRAGA-SILVA, Rodrigo A.; CASTRO, Carlos Henrique; RAIZADA, Mohan K.; SANTOS, Robson A. S. New cardiovascular and pulmonary therapeutic strategies based on the angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis. International Journal of Hypertension, London, v. 2012, p. 1-13, 2012.