Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/15815
Tipo do documento: Artigo
Título: Oleanolic acid acrylate elicits antidepressant-like effect mediated by 5-HT 1A receptor
Autor: Fajemiroye, James Oluwagbamigbe
Polepally, Prabhakar R.
Chaurasiya, Narayan D.
Tekwani, Babu L.
Zjawiony, Jordan K.
Costa, Elson Alves
Abstract: The development of new drugs for the treatment of depression is strategic to achieving clinical needs of patients. This study evaluates antidepressant-like effect and neural mechanisms of four oleanolic acid derivatives i.e. acrylate (D1), methacrylate (D2), methyl fumarate (D3) and ethyl fumarate (D4). All derivatives were obtained by simple one-step esterification of oleanolic acid prior to pharmacological screening in the forced swimming (FS) and open field (OF) tests. Pharmacological tools like α-methyl-p-tyrosine (AMPT, catecholamine depletor), p-chlorophenylalanine (serotonin depletor), prazosin (PRAZ, selective α1-receptor antagonist), WAY-100635 (selective serotonin 5-HT 1A receptor antagonist) as well as monoamine oxidase (MAO) and functional binding assays were conducted to investigate possible neural mechanisms. In the FS test, D1 showed the most promising antidepressant-like effect without eliciting locomotor incoordination. Unlike group of mice pretreated with AMPT 100 mg/kg, PCPA 100 mg/kg or PRAZ 1 mg/kg, the effect of D1 was attenuated by WAY-100635 0.3 mg/kg pretreatment. D1 demonstrated moderate inhibition of MAO-A (IC 50 = 48.848 ± 1.935 μM), potency (pEC 50 = 6.1 ± 0.1) and intrinsic activity (E max = 26 ± 2.0%) on 5-HT 1A receptor. In conclusion, our findings showed antidepressant-like effect of D1 and possible involvement of 5-HT 1A receptor.
País: Alemanha
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: FAJEMIROYE, James O. et al. Oleanolic acid acrylate elicits antidepressant-like effect mediated by 5-HT1A receptor. Scientific Reports, Berlim, v. 2015, n. 11582, p. 1-12, July 2015.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1038/srep11582
Identificador do documento: 10.1038/srep11582
URI: http://repositorio.bc.ufg.br/handle/ri/15815
Data de publicação: Jul-2015
Aparece nas coleções:ICB - Artigos publicados em periódicos

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