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Tipo do documento: Artigo
Título: Mechanisms underlying the antinociceptive, antiedematogenic, and anti-inflammatory activity of the main flavonoid from
Autor: Ferreira, Raquel Teixeira
Coutinho, Marcela Araújo Soares
Malvar, David do Carmo
Costa, Elson Alves
Florentino, Iziara Ferreira
Costa, Sônia Soares
Vanderlinde, Frederico Argollo
Abstract: Kalanchoe pinnata (KP) is popularly used for treating inflammatory diseases. This study investigated the antinociceptive, antiedematogenic, and anti-inflammatory potential of the subcutaneous administration of KP flower aqueous extract (KPFE), its ethyl acetate (EtOAcF) and butanol (BuOHF) fractions, and the main KP flavonoid [quercetin 3-O-α-L-arabinopyranosyl (1 → 2) α-L-rhamnopyranoside] (KPFV) in mice, as well as its possible mechanisms of action. KPFE (30–300 mg/kg) and KPFV (1– 10 mg/kg) inhibited the acetic acid-induced writhing (ID 50 = 164.8 and 9.4 mg/kg, resp.). KPFE (300 mg/kg), EtOAcF (12 mg/kg), BuOHF (15 mg/kg), or KPFV (0.3–3.0 mg/kg) reduced leukocyte migration on carrageenan-induced pleurisy (ID 50 = 2.0 mg/kg for KPFV). KPFE (3–30 mg/kg) and KPFV (0.3–3.0 mg/kg) reduced the croton oil-induced ear edema (ID 50 = 4.3 and 0.76 mg/kg, resp.). KPFE and KPFV reduced the TNF-α concentration in the pleural exudates on carrageenan-induced pleurisy test. Moreover, KPFV inhibited COX-1 (IC 50 = 22.1 μg/mL) and COX-2 (IC 50 > 50 μg/mL). The selectivity index (COX-1 IC 50 /COX-2 IC 50 ) was <0.44. These results indicate that KPFE and KPFV produced antinociceptive, antiedematogenic, and anti-inflammatory activities through COX inhibition and TNF-α reduction, revealing that the main flavonoid in KP flowers and leaves plays an important role in the ethnomedicinal use of the plant.
País: Gra-bretanha
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: FERREIRA, Raquel Teixeira et al. Mechanisms underlying the antinociceptive, antiedematogenic, and anti-inflammatory activity of the main flavonoid from. Evidence-Based Complementary and Alternative Medicine, London, v. 2014, p. 1-8, 2014.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1155/2014/429256
Identificador do documento: 10.1155/2014/429256
URI: http://repositorio.bc.ufg.br/handle/ri/15818
Data de publicação: 2014
Aparece nas coleções:ICB - Artigos publicados em periódicos

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