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Tipo do documento: Artigo
Título: Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju
Autor: Vanderlinde, Frederico Argollo
Rocha, Fabio Fagundes da
Malvar, David do Carmo
Ferreira, Raquel Teixeira
Costa, Elson Alves
Florentino, Iziara Ferreira
Guilhon, Giselle Maria Skelding Pinheiro
Lima, Thereza Christina Monteiro de
Abstract: Mikania lindleyana DC., Asteraceae (sucuriju), grows in the Amazon region, where is frequently used to treat pain, inflammatory diseases and scarring. This study was carried out to investigate phytochemical profile accompanied by in vivo antinociceptive and anti-inflammatory screening of n-hexane (HE), dichloromethane (DME) and methanol (ME) extracts obtained from the aerial parts of the plant. The oral administration of ME (0.1, 0.3, 1 g/kg) caused a dose-related reduction (16.2, 42.1 e 70.2%) of acetic acid-induced abdominal writhing while HE and DME (1 g/kg, p.o.) were ineffective. In the hot plate test, ME (300 mg/kg, p.o.) increased the latency of heat stimulus between 30 and 120 min and inhibited the first (45%) and second (60%) phases of nociception in the formalin test. The antinociception induced by ME or positive control fentanyl (150 μg/kg, s.c.) in hot plate and formalin tests was prevented by naloxone (3 mg/kg, s.c.). When submitted to the carrageenan-induced peritonitis test, ME (0.5, 1.0, 2.0 g/kg, p.o.) impaired leukocyte migration into the peritoneal cavity by 46.8, 59.4 and 64.8% respectively, while positive control dexamethasone (2 mg/kg, s.c.), inhibited leukocyte migration by 71.1%. These results indicate that the antinociception obtained after oral administration of methanol extract of M. lindleyana involves anti-inflammatory mechanisms accompanied with opioid-like activity which could explain the use of the specie for pain and inflammatory diseases.
Palavras-chave: Mikania lindleyana
País: Brasil
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: VANDERLINDE, Frederico A. et al. Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju. Revista Brasileira de Farmacognosia, Curitiba, v. 22, n. 1, p. 150-156, Jan./Feb. 2012.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1590/S0102-695X2011005000190
Identificador do documento: 10.1590/S0102-695X2011005000190
Data de publicação: Fev-2012
Aparece nas coleções:ICB - Artigos publicados em periódicos

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