Use este identificador para citar ou linkar para este item:
Tipo do documento: Artigo
Título: Anxiolytic-like and sedative effects Hydrocotyle umbellata extract in mice
Autor: Rocha, Fabio Fagundes da
Almeida, Claudio da Silva
Santos, Rafael Teixeira dos
Santama, Suely Alencar
Costa, Elson Alves
Paula, José Realino de
Vanderlinde, Frederico Argollo
Abstract: The plant Hydrocotyle umbellata L., Araliaceae (water pennywort), is widely used in Brazilian folk medicine to reduce anxiety. This work investigates the anxiolytic-like effects of the ethanol extract from H. umbellata subterraneous parts as well as the extract’s other putative central nervous system effects that could justify its common use. Oral dosing of the extract (0.3 and 1 g/kg) clearly showed an anxiolytic-like profile in the elevated plus maze test where it increased the percentage of entries into and the time spent in the open arms of the maze. In the marble-burying test, the extract induced anxiolytic- like effects only at a dose of 1 g/kg, which also causes mild sedative properties in other models. The sedated state was characterized by a slight reduction in spontaneous exploratory activity during the open field test and a potentiating of pentobarbital-induced hypnosis. No signs of motor impairment were detected in the rota rod or chimney tests. The extract did not show antidepressant properties in mice as assessed by the forced swimming test. These results support the use of H. umbellata in Brazilian folk medicine as an anxiolytic and contribute to the scientific knowledge of this possible phytotherapeutic resource.
Palavras-chave: Anxiolytic
Elevated plus maze
Hydrocotyle umbellata
Marble burying test
País: Brasil
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: ROCHA, Fábio F. et al. Anxiolytic-like and sedative effects of Hydrocotyle umbellata extract in mice. Revista Brasileira de Farmacognosia, Curitiba, v. 21, n. 1, p. 115-120, Jan./Feb. 2011.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1590/S0102-695X2011005000018
Identificador do documento: 10.1590/S0102-695X2011005000018
Data de publicação: Fev-2011
Aparece nas coleções:ICB - Artigos publicados em periódicos

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
Artigo - Fabio Fagundes da Rocha - 2011.pdf714,95 kBAdobe PDFThumbnail

Este item está licenciada sob uma Licença Creative Commons Creative Commons