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dc.creatorRocha, Fabio Fagundes da-
dc.creatorAlmeida, Claudio da Silva-
dc.creatorSantos, Rafael Teixeira dos-
dc.creatorSantama, Suely Alencar-
dc.creatorCosta, Elson Alves-
dc.creatorPaula, José Realino de-
dc.creatorVanderlinde, Frederico Argollo-
dc.identifier.citationROCHA, Fábio F. et al. Anxiolytic-like and sedative effects of Hydrocotyle umbellata extract in mice. Revista Brasileira de Farmacognosia, Curitiba, v. 21, n. 1, p. 115-120, Jan./Feb. 2011.pt_BR
dc.identifier.issne- 1981-528X-
dc.description.abstractThe plant Hydrocotyle umbellata L., Araliaceae (water pennywort), is widely used in Brazilian folk medicine to reduce anxiety. This work investigates the anxiolytic-like effects of the ethanol extract from H. umbellata subterraneous parts as well as the extract’s other putative central nervous system effects that could justify its common use. Oral dosing of the extract (0.3 and 1 g/kg) clearly showed an anxiolytic-like profile in the elevated plus maze test where it increased the percentage of entries into and the time spent in the open arms of the maze. In the marble-burying test, the extract induced anxiolytic- like effects only at a dose of 1 g/kg, which also causes mild sedative properties in other models. The sedated state was characterized by a slight reduction in spontaneous exploratory activity during the open field test and a potentiating of pentobarbital-induced hypnosis. No signs of motor impairment were detected in the rota rod or chimney tests. The extract did not show antidepressant properties in mice as assessed by the forced swimming test. These results support the use of H. umbellata in Brazilian folk medicine as an anxiolytic and contribute to the scientific knowledge of this possible phytotherapeutic resource.pt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectElevated plus mazept_BR
dc.subjectHydrocotyle umbellatapt_BR
dc.subjectMarble burying testpt_BR
dc.titleAnxiolytic-like and sedative effects Hydrocotyle umbellata extract in micept_BR
dc.publisher.departmentInstituto de Ciências Biológicas - ICB (RG)pt_BR
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