Evaluation of the antinociceptive and anti-inflammatory effects of the acetone extract from Anacardium occidentale L.
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Data
2009-09
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Resumo
The stem bark of Anacardium occidentale L. (Anacardiaceae), commonly called cashew, is used in
Brazilian traditional medicine for the treatment of gastric and inflammatory disorders. The present
study was carried out to investigate the in vivo anti-inflammatory activities of the acetone extract (AE)
of the stem bark of A. occidentale. We evaluated the pharmacological activities of this plant material
through the analgesic, antiedematogenic and chemotaxic inhibitory effects produced by the AE. The
oral administration (p.o.) of mice with the AE (0.1, 0.3 and 1.0 g/kg) or positive control indomethacin
(10 mg/kg) inhibited acetic acid-induced writhing by 18.9, 35.9, 62.9 and 68.9%, respectively (ID 50% =
530 mg/kg). The highest dose of the AE was able to inhibit croton oil-induced ear edema formation by
56.8% (indomethacin at 10 mg/kg, p.o. - 57.6% inhibition). When submitted to the carrageenan-induced
peritonitis test, the AE (0.1, 0.3 and 1.0 g/kg, p.o.) impaired leukocyte migration into the peritoneal
cavity by 24.8, 40.5 and 49.6%, respectively. The positive control, dexamethasone (2 mg/kg, s.c.),
inhibited leukocyte migration by 66.9%. These results indicate the presence of anti-inflammatory and
antinociceptive principles in the acetone extract of Anacardium occidentale, and reinforce the plant’s
potential therapeutic use against pain and inflammatory diseases.
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Anacardium occidentale L./analgesic activity, Cashew, Anacardium occidentale L./anti-inflammatory activity, Anacardium occidentale L./antiedematogenic activity, Anacardium occidentale L./atividade analgésica, Cajueiro, Anacardium occidentale L./atividade antiinflamatória, Anacardiaceae, Anacardium occidentale L./atividade antiedematogenica
Citação
VANDERLINDE, Frederico Argollo et al. Evaluation of the antinociceptive and anti-inflammatory effects of the acetone extract from Anacardium occidentale L. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 45, n. 3, p. 437-442, July/Sept. 2009.