Involvement of catecholaminergic medullary pathways in cardiovascular responses to acute changes in circulating volume
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Data
2011-09
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Resumo
Water deprivation and hypernatremia are major challenges for water and sodium homeostasis. Cellular integrity requires
maintenance of water and sodium concentration within narrow limits. This regulation is obtained through engagement of mul-
tiple mechanisms and neural pathways that regulate the volume and composition of the extracellular fluid. The purpose of this
short review is to summarize the literature on central neural mechanisms underlying cardiovascular, hormonal and autonomic
responses to circulating volume changes, and some of the findings obtained in the last 12 years by our laboratory. We review
data on neural pathways that start with afferents in the carotid body that project to medullary relays in the nucleus tractus solitarii
and caudal ventrolateral medulla, which in turn project to the median preoptic nucleus in the forebrain. We also review data sug-
gesting that noradrenergic A1 cells in the caudal ventrolateral medulla represent an essential link in neural pathways controlling
extracellular fluid volume and renal sodium excretion. Finally, recent data from our laboratory suggest that these structures may
also be involved in the beneficial effects of intravenous infusion of hypertonic saline on recovery from hemorrhagic shock.
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Palavras-chave
Baroreceptors, Blood pressure, A1 noradrenergic neurons, Hypertonic saline, AV3V, Renal vascular conductance
Citação
CRAVO, S. L.; LOPES, O. U.; PEDRINO, G. R. Involvement of catecholaminergic medullary pathways in cardiovascular responses to acute changes in circulating volume. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 44, n. 9, p. 877-882, Sept. 2011.