Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/16099
Tipo do documento: Artigo
Título: Presence of maternal anti-HBs antibodies does not influence hepatitis B vaccine response in brazilian neonates
Autor: Junqueira, Ana Luiza Neto
Tavares, Viviane Rodrigues
Martins, Regina Maria Bringel
Alexandre, Kamilla Venâncio Frauzino
Silva, Agabo Macedo da Costa e
Rodrigues, Izolina Maria Xavier
Minamisava, Ruth
Teles, Sheila Araújo
Abstract: Recently, it was suggested that maternal hepatitis B surface antigen antibodies (anti-HBs) acquired transplacentally could play a negative role in newborn infants’ immune response to the hepatitis B vaccine. We compared the hepatitis B virus (HBV) vaccine response in infants born to mothers previously vaccinated against HBV (n = 91) to infants born to mothers who were not previously vaccinated (n = 221). All newborn infants received three intramuscular doses (10 μg) of HBV vaccine (Butang®) at 0,1 and six months. The first dose was administered at the maternity hospital within 12 h of birth. The geometric mean titres of anti-HBs were not different among newborn infants born to mothers who were anti-HBs-negative (492.7 mIU/mL) and anti-HBs-positive (578.7 mIU/mL) (p = 0.38). Eight infants did not respond to the HBV vaccine. Of them, six were born to anti-HBs-negative mothers and two were born to mothers with anti-HBs titres less than 50 mlU/mL. Despite the mother’s anti-HBs-positive status, our data show a good immunogenicity of the Brazilian HBV recombinant vaccine in neonates.
Palavras-chave: Hepatitis B vaccine
Newborn infants
Antibody response
País: Brasil
Unidade acadêmica: Faculdade de Enfermagem - FEN (RG)
Citação: JUNQUEIRA, Ana Luiza N. et al. Presence of maternal anti-HBs antibodies does not influence hepatitis B vaccine response in brazilian neonates. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 106, n. 1, p. 113-116, Feb. 2011.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1590/S0074-02762011000100018
Identificador do documento: 10.1590/S0074-02762011000100018
URI: http://repositorio.bc.ufg.br/handle/ri/16099
Data de publicação: Fev-2011
Aparece nas coleções:FEN - Artigos publicados em periódicos

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