Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/16115
Tipo do documento: Artigo
Título: Seroepidemiology of hepatitis B virus infection and high rate of response to hepatitis B virus Butang® vaccine in adolescents from low income families in central Brazil
Autor: Oliveira, Michele Dias da Silva
Martins, Regina Maria Bringel
Matos, Marcos André
Souto, Renata Carneiro Ferreira
Matos, Márcia Alves Dias de
Carneiro, Megmar Aparecia dos Santos
Junqueira, Ana Luiza Neto
Teles, Sheila Araújo
Abstract: In order to evaluate the seroepidemiology and response to Butang® vaccine in adolescents from low income families in Central Brazil, blood samples of 664 adolescents were tested for hepatitis B surface antigen (HBsAg), hepatitis B core antibody (anti-HBc), and hepatitis B surface antibody (anti-HBs) markers, and multiple logistical regression analysis was carried out to determine variables associated with hepatitis B virus (HBV) infection markers. Further, three 20 μg Butang® vaccine doses were offered to all susceptible individuals (n = 304). Among those who accepted them (n = 182), the seroresponse was evaluated in 170 individuals by quantitative anti-HBs. An overall HBV prevalence of 5.9% was found: four adolescents were HBsAg positive, 24 were anti-HBc, anti-HBsreactive, and 11 were anti-HBc only. The analyse of risk factors showed that age 16-19 years, place of birth outside Goiás, school B and body piercing were statistically associated with HBV infection markers (p < 0.05). All 170 adolescents responded to Butang®, and a geometric mean titer (GMT) of 4344 mUI/ml was obtained. These results reinforce the importance of hepatitis B vaccine in adolescents despite of the HBV regional endemicity, and suggest that three doses of 20 μg of the Butang® should guarantee protective anti-HBs levels to individuals at a critical time for hepatitis B acquiring such as latter adolescence and adulthood.
Palavras-chave: Hepatitis B
Adolescents
Vaccine
Brazil
País: Brasil
Unidade acadêmica: Faculdade de Enfermagem - FEN (RG)
Citação: OLIVEIRA, Michele Dias da S. et al. Seroepidemiology of hepatitis B virus infection and high rate of response to hepatitis B virus Butang® vaccine in adolescents from low income families in central Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, n. 3, p. 251-256, May 2006.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1590/S0074-02762006000300004
Identificador do documento: 10.1590/S0074-02762006000300004
URI: http://repositorio.bc.ufg.br/handle/ri/16115
Data de publicação: Mai-2006
Aparece nas coleções:FEN - Artigos publicados em periódicos

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