Modulatory effects of Duguetia furfuracea (A. St. Hil) Benth. and Hook. f. in Drosophila melanogaster somatic and germinative cells
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Data
2011
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Resumo
Mutagenic and antimutagenic activities of the
medicinal plant Duguetia furfuracea were assessed using SMART/
wing and ring-X-loss tests. For the ring-X-loss test, 2- to 3-day-old
Drosophila melanogaster ring-X-lineage males and virgin ywsn 3
females received D. furfuracea infusion at doses of 0.085, 0.042, or
0.014 g/mL for 24 h. We found that D. furfuracea did not produce
any mutagenic effects in D. melanogaster germinative cells. The
somatic cells of D. melanogaster were analyzed using the SMART/
wing test involving three lineages - mwh, flr 3 , and ORR - and the
same doses of D. furfuracea infusion employed in the ring-X-loss
test, as well as 20 mM urethane. The results of both standard (ST)
and high bioactivation (HB) crosses showed absence of mutagenic
activity of D. furfuracea. In contrast, in both ST and HB crosses, we observed a modulatory effect of D. furfuracea against the genotoxic
activity of urethane.
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Palavras-chave
Antimutagenicity, Mutagenicity, Duguetia furfuracea, Genotoxicity
Citação
COELHO, L. S. et al. Modulatory effects of Duguetia furfuracea (A. St Hil) Benth and Hook.f in Drosophila melanogaster somatic and germinative cells. Genetics and Molecular Research, Ribeirão Preto, v. 10, n. 1, p. 75-85, 2011.