Avaliação dos níveis das hemoglobinas A2 e Fetal dosadas por HPLC em estudantes hígidos da Universidade Católica de Goiás
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Data
2006
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Resumo
Thalassemias are hemoglobin hereditary disturbances related to the racial mixing and gene dynamics in each popula-
tion. There are two groups of thalassemias, alfa and beta. The prevention is the precocious diagnostic, education and clinical obser-
vance of the affected individuals. Among the used tests for beta thalassemias are the measurement of HbA2 and fetal hemoglobins.
In this study we evaluate the variation levels of hemoglobins A2 and F in 214 healthy patients that are also students of the Catholic
University of Goias. The hemoglobin measurement was carried out by high performance liquid chromatography (HPLC) methodology.
The results show that 12,6% and 5,1% of the patients presented values of HbA2 and HbF above the limits of the methodology. Howe-
ver, we observed that the reference values used nowadays for HbA2 fraction are within very narrow limits. We conclude which it is
necessary a revision and consequently a change toward an amplification of these adopted reference values for HPLC methodology ai-
ming a better use in the beta thalassemias diagnostic.
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Talassemia beta, HPLC, Hemoglobina A 2, Diagnóstico laboratorial, Hemoglobina fetal
Citação
MELO-REIS, Paulo Roberto de et al. Avaliação dos níveis das hemoglobinas A2 e Fetal dosadas por HPLC em estudantes hígidos da Univrsidade Católica de Goiás. Revista Brasileira de Análises Clínicas, Rio de Janeiro, v. 38, n. 4, p. 231-233, 2006.