Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/16242
Tipo do documento: Artigo
Título: Altered β-catenin expression in oral mucosal dysplasia: a comparative study
Autor: Silva, Brunno Santos de Freitas
Castro, Caroline Alves de
Zeidler, Sandra Lúcia Ventorin von
Sousa, Suzana Cantanhede Orsini Machado de
Batista, Aline Carvalho
Silva, Fernanda Paula Yamamoto
Abstract: Obective: Thee current study aimed to investigate the B-catenin expression in oral leukoplakia (OL) with different degrees of epithelial dysplasia and normal oral mucosa. aterial and ethods: ormalin ed paraf n em edded tissue samples of OL (mild dysplasia n=19, moderate dysplasia n=13, and severe dysplasia n=7), and 10 normal oral mucosa (control group) were su mitted to immunohistochemical reactions to anti catenin primary anti ody. ualitative catenin analysis was performed ased on the percentage of positive cells. The cellular location and the epithelial layer were also considered. The Chi-square test and the Fisher’s exact test were used to verify possible differences in the -catenin expression among the OL groups. p-value of 0.0 was considered statistically signi cant. esults: embranous expression of -catenin in parabasal and basal layers was gradually lost in the higher degrees of epithelial dysplasia. In normal oral mucosa, -catenin was detected only in the cytoplasmic membrane. owever, a signi cant increase in cytoplasmic -catenin could be observed between mild and moderate dysplasia (Fisher Exact test - p<0.001) and between mild and severe dysplasia (p<0.001). Conclusions: The -catenin cytoplasmic expression observed in this study may represent the initial stage of modi cations in the E-cadherin-catenin complex, along with morphological cellular changes.
Palavras-chave: Beta-catenin
Oral leukoplakia
Oral dysplasia
Oral cancer
País: Brasil
Unidade acadêmica: Faculdade de Odontologia - FO (RG)
Citação: SILVA, Brunno Santos de Freitas et al. Altered β-catenin expression in oral mucosal dysplasia: a comparative study. Journal of Applied Oral Science, Bauru, v. 23, n. 5, p. 472-478, 2015.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1590/1678-775720150150
Identificador do documento: 10.1590/1678-775720150150
URI: http://repositorio.bc.ufg.br/handle/ri/16242
Data de publicação: 2015
Aparece nas coleções:FM - Artigos publicados em periódicos

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