Acute immune response to mycobacterium massiliense in C57BL/6 and BALB/c mice
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2010-04
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Mycobacterium massiliense is an environmental opportunistic pathogen that has been associated with soft
tissue infection after minor surgery. We studied the acute immune response of C57BL/6 and BALB/c mice
infected intravenously with 10 6 CFU of an M. massiliense strain isolated from a nosocomial infection in Brazil.
The results presented here show that M. massiliense is virulent and pathogenic to both C57BL/6 and BALB/c
mice, inducing a granulomatous inflammatory reaction that involves the activation of macrophages, dendritic
cells, and natural killer cells induced by gamma interferon and interleukin-17 (IL-17) in C57BL/6 mice and by
IL-12 in BALB/c mice.
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SOUSA, Eduardo Martins de et al. Acute Immune response to mycobacterium massiliense in C57BL/6 and BALB/c mice. Infection and Immunity, Washington, v. 78, n. 4, p. 1571-1581, Abr. 2010.