Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/16277
Tipo do documento: Artigo
Título: Long-term effects of nifedipine on human gingival epithelium: a histopathological and immunohistochemical study
Autor: Castro, Luciano Alberto de
Alves, Larissa Santana Arantes Elias
Leite, Angélica Ferreira Oton
Spíndula Filho, José Vieira de
Leles, Cláudio Rodrigues
Batista, Aline Carvalho
Mendonca, Elismauro Francisco de
Abstract: The chronic usage of nifedipine is associated with the appearance of gingival overgrowth (GO). The frequency of GO associated with chronic nifedipine therapy remains controversial and the possible subclinical effects of this drug on the gingival epithelium should be investigated. We investigated the epithelial proliferation index and apoptosis rate, and their association with epithelial enlargement. Proliferation (Ki67 and Cyclin B1) and apoptosis (BCL2, Bax and p53) markers were identified by immunohistochemistry in twenty-one samples of gingival tissue from patients undergoing chronic treatment with nifedipine and in eleven samples of gingival tissue from healthy patients who did not use drugs associated with GO (control). Our results show that the epithelial tissue of nifedipine users has considerably longer rete pegs compared to control (P = 0.01). However, the density of Ki67 + and Cyclin B1 + cells was similar in both groups. Regarding apoptosis, we found more BCL2 + cells in the nifedipine group when compared to controls (P = 0.12). An increase in Bax + cells in the nifedipine group compared to control (P =0.003) was also seen, and slightly lower levels of p53 + expression were observed (P = 0.51). Our results suggest that the chronic use of nifedipine is not associated with subclinical changes in gingival tissue. (J Oral Sci 52, 55-62, 2010).
Palavras-chave: Cell proliferation
Gingival overgrowth
Apoptosis
Adverse effect
Nifedipine
País: Outros
Unidade acadêmica: Faculdade de Odontologia - FO (RG)
Citação: CASTRO, Luciano A. et al. Long-term effects of nifedipine on human gingival epithelium: a histopathological and immunohistochemical study. Journal of Oral Science, Tokyo, v. 52, n. 1, p. 55-62, 2010.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.2334/josnusd.52.55
Identificador do documento: 10.2334/josnusd.52.55
URI: http://repositorio.bc.ufg.br/handle/ri/16277
Data de publicação: 2010
Aparece nas coleções:FM - Artigos publicados em periódicos

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
Artigo - Luciano Alberto de Castro. - 2010.pdf646,28 kBAdobe PDFThumbnail
Baixar/Abrir


Este item está licenciada sob uma Licença Creative Commons Creative Commons