Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/16292
Tipo do documento: Artigo
Título: Lack of association between ACE indel polymorphism and cardiorespiratory fitness in physically active and sedentary young women
Autor: Verlengia, Rozangela
Rebelo, Ana Cristina Silva
Crisp, Alex Harley
Kunz, Vandeni Clarice
Cordeiro, Marco Antônio dos Santos Carneiro
Hirata, Mario Hiroyuki
Hirata, Rosario Dominguez Crespo
Silva, Ester
Abstract: Background: Polymorphisms at the angiotensin-converting enzyme gene (ACE), such as the indel [rs1799752] variant in intron 16, have been shown to be associated with aerobic performance of athletes and non-athletes. However, the relationship between ACE indel polymorphism and cardiorespiratory fitness has not been always demonstrated. Objectives: The relationship between ACE indel polymorphism and cardiorespiratory fitness was investigated in a sample of young Caucasian Brazilian women. Patients and Methods: This study investigated 117 healthy women (aged 18 to 30 years) who were grouped as physically active (n = 59) or sedentary (n = 58). All subjects performed an incremental exercise test (ramp protocol) on a cycle-ergometer with 20-25 W/min increments. Blood samples were obtained for DNA extraction and to analyze metabolic and hormonal profiles. ACE indel polymorphism was determined by polymerase chain reaction (PCR) and fragment size analysis. Results: The physically active group had higher values of peak oxygen uptake (VO 2 peak), carbon dioxide output (VCO 2 ), ventilation (VE) and power output than the sedentary group (P < 0.05) at the peak of the exercise test. However, heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) did not differ between groups. There was no relationship between ACE indel polymorphism and cardiorespiratory variables during the test in both the physically active and sedentary groups, even when the dominant (DD vs. D1 + 2) and recessive (2 vs. DI + DD) models of inheritance were tested. Conclusions: These results do not support the concept that the genetic variation at the ACE locus contributes to the cardiorespiratory responses at the peak of exercise test in physically active or sedentary healthy women. This indicates that other factors might mediate these responses, including the physical training level of the women.
Palavras-chave: Exercise test
Motor activity
Angiotensin-converting enzyme
Genetic
Polymorphism
País: Outros
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: VERLENGIA, Rozangela et al. Lack of association between ACE indel polymorphism and cardiorespiratory fitness in physically active and sedentary young women. Asian Journal of Sports Medicine, Tehran , v. 5, n. 3, p. 1-7, Sept. 2014.
Tipo de acesso: Acesso Aberto
URI: http://repositorio.bc.ufg.br/handle/ri/16292
Data de publicação: Set-2015
Aparece nas coleções:FM - Artigos publicados em periódicos

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