Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/16293
Tipo do documento: Artigo
Título: Lack of association of estrogen receptor alpha gene polymorphisms with cardiorespiratory and metabolic variables in young women
Autor: Rebelo, Ana Cristina Silva
Verlengia, Rozangela
Kunz, Vandeni Clarice
Tamburús, Nayara Yamada
Maureira, Alvaro Danilo Cerda
Hirata, Rosario Dominguez Crespo
Hirata, Mario Hiroyuki
Silva, Ester da
Abstract: This study examined the association of estrogen receptor alpha gene (ESR1) polymorphisms with cardiorespiratory and metabolic parameters in young women. In total, 354 healthy women were selected for cardiopulmonary exercise testing and short-term heart rate (HR) variability (HRV) evaluation. The HRV analysis was determined by the temporal indices rMSSD (square root of the mean squared differences of successive R–R intervals (RRi) divided by the number of RRi minus one), SDNN (root mean square of differences from mean RRi, divided by the number of RRi) and power spectrum components by low frequency (LF), high frequency (HF) and LF/HF ratio. Blood samples were obtained for serum lipids, estradiol and DNA extraction. ESR1 rs2234693 and rs9340799 polymorphisms were analyzed by PCR and fragment restriction analysis. HR and oxygen uptake (VO 2 ) values did not differ between the ESR1 polymorphisms with respect to autonomic modulation. We not find a relationship between ESR1 T–A, T–G, C–A and C–G haplotypes and cardiorespiratory and metabolic variables. Multiple linear regression analysis demonstrated that VO 2 , total cholesterol and triglycerides influence HRV (p < 0.05). The results suggest that ESR1 variants have no effect on cardiorespiratory and metabolic variables, while HRV indices are influenced by aerobic capacity and lipids in healthy women.
Palavras-chave: Estrogen aerobic capacity
Heart rate variability
Lipids receptor-α gene polymorphisms
País: Suica
Unidade acadêmica: Instituto de Ciências Biológicas - ICB (RG)
Citação: REBELO, Ana Cristina et al. Lack of association of estrogen receptor alpha gene polymorphisms with cardiorespiratory and metabolic variables in young women. International Journal of Molecular Sciences, Basel, v. 13, n. 10, p. 13691-13703, 2012.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.3390/ijms131013691
Identificador do documento: 10.3390/ijms131013691
URI: http://repositorio.bc.ufg.br/handle/ri/16293
Data de publicação: 2012
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