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Tipo do documento: Artigo
Título: Recombinant BCG: innovations on an old vaccine. Scope of BCG strains and strategies to improve long-lasting memory
Autor: Costa, Adeliane Castro da
Nogueira, Sarah Veloso
Kipnis, André
Junqueira-Kipnis, Ana Paula
Abstract: Bacille Calmette–Guérin (BCG), an attenuated vaccine derived from Mycobacterium bovis, is the current vaccine of choice against tuberculosis (TB). Despite its protection against activeTB in children, BCG has failed to protect adults againstTB infection and active disease development, especially in developing countries where the disease is endemic. Currently, there is a significant effort toward the development of a newTB vaccine.This review article aims to address publications on recombinant BCG (rBCG) published in the last 5 years, to highlight the strategies used to develop rBCG, with a focus on the criteria used to improve immunological memory and protection compared with BCG. The literature review was done in April 2013, using the key words TB, rBCG vaccine, and memory. This review discusses the BCG strains and strategies currently used for the modification of BCG, including: overexpression of Mycobacterium tuberculosis (Mtb) immunodominant antigens already present in BCG; gene insertion of immunodominant antigens from Mtb absent in the BCG vaccine; combination of introduction and overexpression of genes that are lost during the attenuation process of BCG; BCG modifications for the induction of CD8CT-cell immune responses and cytokines expressing rBCG. Among the vaccines discussed,VPM1002, also called rBCGDureC:hly, is currently in human clinical trials. Much progress has been made in the effort to improve BCG, with some promising candidates, but considerable work is still required to address functional long-lasting memory.
Palavras-chave: rBCG
Long-term memory
Strain differences
País: Suica
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: COSTA, Adeliane Castro da; NOGUEIRA, Sarah Veloso; KIPNIS, André; JUNQUEIRA-KIPNIS, Ana Paula. Recombinant BCG: innovations on an old vaccine. Scope of BCG strains and strategies to improve long-lasting memory. Frontiers in Immunology, Lausanne, v. 5, p. 1-9, 2014.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.3389/fimmu.2014.00152
Identificador do documento: 10.3389/fimmu.2014.00152
Data de publicação: 7-Abr-2014
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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