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Tipo do documento: Artigo
Título: Humoral response to HspX and GlcB to previous and recent infection by Mycobacterium tuberculosis
Autor: Rabahi, Marcelo Fouad
Junqueira-Kipnis, Ana Paula
Reis, Michelle Cristina Guerreiro dos
Oelemann, Walter
Conde, Marcus Barreto
Abstract: Background: Tuberculosis (TB) remains a major world health problem. Around 2 billions of people are infected by Mycobacterium tuberculosis, the causal agent of this disease. This fact accounts for a third of the total world population and it is expected that 9 million people will become infected each year. Only approximately 10% of the infected people will develop disease. However, health care workers (HCW) are continually exposed to the bacilli at endemic sites presenting increased chance of becoming sick. The objective of this work was to identify LTBI (latent tuberculosis infection) among all asymptomatic HCW of a Brazilian Central Hospital, in a three year follow up, and evaluate the humoral response among HCW with previous and recent LTBI to recombinant HspX and GlcB from M. tuberculosis. Methods: Four hundred and thirty seven HCW were screened and classified into three different groups according to tuberculin skin test (TST) status: uninfected, previous LTBI and recent LTBI. ELISA test were performed to determine the humoral immune response to HspX and GlcB. Results: The levels of IgG and IgM against the HspX and GlcB antigens were the same among HCW with recent and previous LTBI, as well as among non infected HCW. However, the IgM levels to HspX was significantly higher among HCW with recent LTBI (OD = 1.52 ± 0.40) than among the uninfected (OD = 1.09 ± 0.50) or subjects with previous LTBI (OD = 0.96 ± 0.51) (p < 0.001). Conclusion: IgG and IgM humoral responses to GlcB antigens were similar amongst all studied groups; nevertheless IgM levels against HspX were higher among the recent LTBI/HCW.
País: Gra-bretanha
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: RABAHI, Marcelo Fouad; JUNQUEIRA-KIPNIS, Ana Paula; REIS, Michelle Cristina Guerreiro dos; OELEMANN, Walter; CONDE, Marcus Barreto. Humoral response to HspX and GlcB to previous and recent infection by Mycobacterium tuberculosis. BMC Infectious Diseases, London, v. 7, n. 148, 2007.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1186/1471-2334-7-148
Identificador do documento: 10.1186/1471-2334-7-148
Data de publicação: 31-Dez-2007
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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