Annona coriacea induz efeito genotóxico em camundongos
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Data
2005-06
Título da Revista
ISSN da Revista
Título de Volume
Editor
Marize Campos Valadares
Resumo
This study was designed to evaluate the genetic toxicity of the Annona coriacea using the bone
marrow erythrocyte micronucleus test. The results demonstrated that the seed alcoholic extract of this plant, in
different doses used (50, 100, 200 or 400mg/kg) induced a significant increase in micronucleus frequencies in bone
marrow erythrocytes of mice, when compared to the negative control. In addition, this increase was similar to those
found in the group of mice exposed to the positive control (cyclophosphamide 250mg/kg). These results suggest
that this plant, in this experimental condition, has a significant potential for induce DNA damage.
Descrição
Palavras-chave
Toxicologia genética, Micronúcleo, Araticum, Annona coriacea, Genetic toxicology, Micronuclei
Citação
FAGUNDES, Flávio A.; OLIVEIRA, Leonardo B. de; CUNHA, Luiz Carlos; VALADARES, Marize Campos. Annona coriacea induz efeito genotóxico em Camundongos. Revista Eletrônica de Farmácia, Goiânia, v. 2, n. 1, p. 24-29, jan./jun. 2005. Disponível em: <https://www.revistas.ufg.br/REF/article/view/1944/1877>.