Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/16707
Tipo do documento: Artigo
Título: Low sensitivity of NS1 protein tests evidenced during a dengue type 2 virus outbreak in Santos, Brazil, in 2010
Autor: Felix, Alvina Clara
Romano, Camila Malta
Centrone, Cristiane de Campos
Rodrigues, Célia Lima
Villas-Boas, Lucy
Araújo, Evaldo Stanislau
Matos, Andréia Manso de
Carvalho, Karina Inácio
Martelli, Celina Maria Turchi
Kallas, Èsper Georges
Pannuti, Claúdio Sérgio
Levi, José Eduardo
Abstract: In 2010, a large outbreak of dengue occurred in Santos, Brazil. The detection of the NS1 antigen was used for diagnosis in addi-tion to the detection of IgG, IgM, and RNA. A large number of NS1 false-negative results were obtained. A total of 379 RNA-posi-tive samples were selected for thorough evaluation. NS1 was reactive in 37.7% of cases. Most of the cases were characterized as a secondary infection by dengue 2 virus. Sequencing of NS1 positive and negative isolates did not reveal any mutation that could justify the diagnostic failure. Use of existing NS1 tests in the Brazilian population may present a low negative predictive value, and they should be used with caution, preferentially after performing a validation with samples freshly obtained during the on-going epidemic.
País: Estados unidos
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: FELIX, Alvina Clara et. al. Low sensitivity of NS1 protein tests evidenced during a dengue type 2 virus outbreak in Santos, Brazil, in 2010. Clinical and Vaccine Immunology, Washington, v. 19, n. 12, p. 1972-1976, 2012.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1128/CVI.00535-12
Identificador do documento: 10.1128/CVI.00535-12
URI: http://repositorio.bc.ufg.br/handle/ri/16707
Data de publicação: 24-Nov-2012
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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