Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/16722
Tipo do documento: Artigo
Título: Estimated incidence and genotypes of HIV-1 among pregnant women in central Brazil
Autor: Costa, Zelma Bernardes
Stefani, Mariane Martins de Araujo
Lima, Yanna Andressa Ramos de
Souza, Wayner Vieira de
Siqueira Filha, Noemia Teixeira de
Turchi, Marilia Dalva
Borges, Walter Costa
Gomes Filho, Clidenor
Macedo Filho, José Vicente
Minuzzi, Ana Lúcia
Martelli, Celina Maria Turchi
Abstract: Objective: To estimate the incidence of HIV-1 infection among pregnant women from central-western Brazil. Design: Observational cross-sectional study. Methods: A total of 54,139 pregnant women received antenatal HIV screening from a network of public healthcare centers in 2011. The incidence of confirmed HIV-1 infection was estimated using the Serological Testing Algorithms for Recent HIV Seroconversion (STARHS) methodology and BED-capture enzyme immunoassay (BED-CEIA). The yearly incidence was calculated, and adjusted incidence rates were estimated. For a subgroup of patients, protease and partial reverse transcriptase regions were retrotranscribed from plasma HIV-1 RNA and sequenced after performing a nested polymerase chain reaction. Results: Of the participants, 20% had a pregnancy before the age of 18 and approximately 40% were experiencing their first pregnancy. Of the 54,139 pregnant women screened, 86 had a confirmed HIV-1 diagnosis, yielding an overall prevalence of 1.59 cases per 1000 women (95% CI 1.27–1.96). A higher prevalence was detected in the older age groups, reflecting cumulative exposure to the virus over time. Among the infected pregnant women, 20% were considered recently infected according to the BED-CEIA. The estimated incidence of HIV infection was 0.61 per 1000 person-years (95% CI 0.33-0.89); the corrected incidence was 0.47 per 1000 person-years (95% CI 0.26-0.68). In a subgroup of patients, HIV-1 subtype C (16.7%) was the second most prevalent form after subtype B (66.7%); BF1 recombinants (11.1%) and one case of subtype F1 (5.5%) were also detected. Conclusion: This study highlights the potential for deriving incidence estimates from a large antenatal screening program for HIV. The rate of recent HIV-1 infection among women in their early reproductive years is a public health warning to implement preventive measures.
País: Estados unidos
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: COSTA, Zelma Bernardes et al. Estimated incidence and genotypes of HIV-1 among pregnant women in central Brazil. Plos One, San Francisco, v. 8, n. 11, p. e79189, 2013.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1371/journal.pone.0079189
Identificador do documento: 10.1371/journal.pone.0079189
URI: http://repositorio.bc.ufg.br/handle/ri/16722
Data de publicação: 4-Nov-2013
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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