Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/16733
Tipo do documento: Artigo
Título: Prevalence and genotypes GB virus C/ Hepatitis G virus among blood donors in central Brazil
Autor: Oliveira, Luciana Alves de
Martins, Regina Maria Bringel
Carneiro, Megmar Aparecida dos Santos
Teles, Sheila Araujo
Silva, Simonne Almeida e
Cardoso, Divina das Dôres de Paula
Lampe, Elisabeth
Yoshida, Clara Fumiko Tachibana
Abstract: A survey was conducted in a blood donor population of Central Brazil aiming to investigate the prevalence of GB virus C (GBV-C)/hepatitis G virus (HGV) infection and also to analyze the virus genotypes distribution. A total of 241 voluntary blood donors were interviewed at the State Blood Bank in Goiânia, State of Goiás, Brazil. Blood samples were collected and serum samples tested for GBV-C/HGV RNA by polymerase chain reaction. Genotypes were determined by restriction fragment length polymorphism (RFLP) analysis. Seventeen samples were GBV-C/HGV RNA-positive, resulting in a prevalence of 7.1% (95% CI: 4.2-11.1). A significant trend of GBV-C/HGV RNA positivity in relation to age was observed, with the highest prevalence in donors between 29-39 years old. Ten infected individuals were characterized by reporting parenteral (30%), sexual (18%), both (6%) and intrafamiliar (6%) transmission. However, 7 (40%) GBV-C/HGV RNA-positive donors did not mention any potential transmission route. RFLP analysis revealed the presence of genotypes 1 and 2 of GBV-C/HGV; more precisely, 10 (58.9%) samples were found belonging to the 2b subtype, 4 (23.5%) to the 2a subtype, and 3 (17.6%) to genotype 1. The present data indicate an intermediate endemicity of GBV-C/HGV infection among this blood donor population, and a predomi-nant circulation of genotype 2 (subtype 2b) in Central Brazil.
Palavras-chave: Central Brazil
Hepatitis G virus
GB virus C
Blood donors
Goiânia
País: Brasil
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: OLIVEIRA, Luciana A.; MARTINS, Regina M. B.; CARNEIRO, Megmar A. S.; TELES, Sheila A.; SILVA, Simonne A.; CARDOSO, Divina D. P.; LAMPE, Elisabeth; YOSHIDA, Clara F. T. Prevalence and genotypes GB virus C/ Hepatitis G virus among blood donors in central Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 97, n. 7, p. 953-957, 2002.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1590/S0074-02762002000700005
Identificador do documento: 10.1590/S0074-02762002000700005
URI: http://repositorio.bc.ufg.br/handle/ri/16733
Data de publicação: Out-2002
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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