Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/16827
Tipo do documento: Artigo
Título: Neonatal sepsis and inflammatory mediators
Autor: Machado, Juliana Reis
Soave, Danilo Figueiredo
Silva, Marcos Vinícius da
Menezes, Liliana Borges de
Etchebehere, Renata Margarida
Monteiro, Maria Luiza Gonçalves dos Reis
Reis, Marlene Antônia dos
Corrêa, Rosana Rosa Miranda
Celes, Mara Rúbia Nunes
Abstract: Neonatal sepsis is a major cause of morbidity and mortality and its signs and symptoms are nonspecific, which makes the diagnosis difficult. The routinely used laboratory tests are not effective methods of analysis, as they are extremely nonspecific and often cause inappropriate use of antibiotics. Sepsis is the result of an infection associated with a systemic inflammatory response with production and release of a wide range of inflammatory mediators. Cytokines are potent inflammatory mediators and their serum levels are increased during infections, so changes from other inflammatory effector molecules may occur. Although proinflammatory and anti-inflammatory cytokines have been identified as probable markers of neonatal infection, in order to characterize the inflammatory response during sepsis, it is necessary to analyze a panel of cytokines and not only the measurement of individual cytokines. Measurements of inflammatory mediators bring new options for diagnosing and following up neonatal sepsis, thus enabling early treatment and, as a result, increased neonatal survival. By taking into account the magnitude of neonatal sepsis, the aim of this review is to address the role of cytokines in the pathogenesis of neonatal sepsis and its value as a diagnostic criterion.
País: Gra-bretanha
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: MACHADO, Juliana Reis et al. Neonatal sepsis and inflammatory mediators. Mediators of Inflammation, London, v. 2014, e-269681, 2014.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1155/2014/269681
Identificador do documento: 10.1155/2014/269681
URI: http://repositorio.bc.ufg.br/handle/ri/16827
Data de publicação: 30-Dez-2014
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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