Identificação da desvenlafaxina, o principal metabólito da Vvnlafaxina, em cápsulas de liberação prolongada
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Data
2010-03
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Editor
Ricardo Menegatti
Resumo
In this work, we describe the identification of desvenlafaxine in extended release capsules
of venlafaxine (VEN) in acid degradation studies. We developed a stability indicating reverse-phase
HPLC method and validated for the analysis of VEN in pharmaceutical formulation. The HPLC method
was linear over the range of 0.45-1.05 mg/ml (r2=0.999). The RSD values for intra- and inter-day
precision studies showed good results (RSD < 2%) and accuracy was greater than 99%. The
degradation studies in acidic media for 24 h showed two additional peaks, which were further
identified by ESI-MS/MS as the desvenlafaxine and the dehydration product of venlafaxine.
Furthermore, desvenlafaxine is the major active metabolite of venlafaxine and has recently been
approved for treatment of major depressive disorder.
Descrição
Palavras-chave
Estudos de degradação, Cápsulas de liberação prolongada, Desvenlafaxina, ESIMS/ MS, Degradation studies, Extended-release capsules, Desvenlafaxine
Citação
CARNEIRO, Wilsione Jose; ANDRADE, Carolina Horta; BRAGA, Rodolpho Campos; OLIVEIRA, Valéria de. Identificação da desvenlafaxina, o principal metabólito da venlafaxina, em cápsulas de liberação prolongada. Revista Eletrônica de Farmácia, Goiânia, v. 7, n. 1, p. 39-53, jan./mar. 2010. Disponível em: <https://revistas.ufg.br/REF/article/view/9594/6650>.