Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/16889
Tipo do documento: Artigo
Título: Multibacillary leprosy patients with high and persistent serum antibodies to leprosy IDRI diagnostic-1/LID-1: higher susceptibility to develop type 2 reactions
Autor: Mizoguti, Danielle de Freitas
Hungria, Emerith Mayra
Freitas, Aline Araújo
Oliveira, Regiane Morillas
Cardoso, Ludimila Paula Vaz
Costa, Mauricio Barcelos
Sousa, Ana Lúcia Maroclo
Duthie, Malcolm S.
Stefani, Mariane Martins de Araújo
Abstract: Leprosy inflammatory episodes [type 1 (T1R) and type 2 (T2R) reactions] represent the major cause of irrevers-ible nerve damage. Leprosy serology is known to be influenced by the patient’s bacterial index (BI) with higher posi-tivity in multibacillary patients (MB) and specific multidrug therapy (MDT) reduces antibody production. This study evaluated by ELISA antibody responses to leprosy Infectious Disease Research Institute diagnostic-1 (LID-1) fusion protein and phenolic glycolipid I (PGL-I) in 100 paired serum samples of 50 MB patients collected in the presence/absence of reactions and in nonreactional patients before/after MDT. Patients who presented T2R had a median BI of 3+, while MB patients with T1R and nonreactional patients had median BI of 2.5+ (p > 0.05). Anti-LID-1 and anti-PGL-I antibodies declined in patients diagnosed during T1R (p < 0.05). Anti-LID-1 levels waned in MB with T2R at diagnosis and nonreactional MB patients (p < 0.05). Higher anti-LID-1 levels were seen in patients with T2R at diagnosis (vs. patients with T1R at diagnosis, p = 0.008; vs. nonreactional patients, p = 0.020) and in patients with T2R during MDT (vs. nonreactional MB, p = 0.020). In MB patients, high and persistent anti-LID-1 antibody levels might be a useful tool for clinicians to predict which patients are more susceptible to develop leprosy T2R.
Palavras-chave: PGL-I
Antibody
Diagnosis
Leprosy reactions
LID-1
Serology
País: Brasil
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: MIZOGUTI, Danielle de Freitas et al. Multibacillary leprosy patients with high and persistent serum antibodies to leprosy IDRI diagnostic-1/LID-1: higher susceptibility to develop type 2 reactions. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 110, n. 7, p. 914-920, 2015.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1590/0074-02760150198
Identificador do documento: 10.1590/0074-02760150198
URI: http://repositorio.bc.ufg.br/handle/ri/16889
Data de publicação: Nov-2015
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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