Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/16909
Tipo do documento: Artigo
Título: European ancestry predominates in neuromielitis optica and multiple sclerosis patients from Brazil
Autor: Souza, Doralina Guimarães Brum
Luizon, Marcelo Rizzatti
Santos, Antonio Carlos dos
Peixoto, Marco Aurélio Lana
Rocha, Cristiane Franklin
Cruz, Maria Lucia Brito da
Oliveira, Enedina Maria Lobato de
Bichuetti, Denis Bernardi
Gabbai, Alberto Alain
Diniz, Denise Sisterolli
Kaimen-Maciel, Damacio Ramón
Frota, Elizabeth Regina Comini
Wiezel, Cláudia Emília Vieira
Muniz, Yara Costa Netto
Costa, Roberta Martins da Silva
Mendes Junior, Celso Teixeira
Donadi, Eduardo Antônio
Barreira, Amilton Antunes
Simões, Aguinaldo Luiz
Abstract: Background: Neuromyelitis optica (NMO) is considered relatively more common in non-Whites, whereas multiple sclerosis (MS) presents a high prevalence rate, particularly in Whites from Western countries populations. However, no study has used ancestry informative markers (AIMs) to estimate the genetic ancestry contribution to NMO patients. Methods: Twelve AIMs were selected based on the large allele frequency differences among European, African, and Amerindian populations, in order to investigate the genetic contribution of each ancestral group in 236 patients with MS and NMO, diagnosed using the McDonald and Wingerchuck criteria, respectively. All 128 MS patients were recruited at the Faculty of Medicine of Ribeirão Preto (MS-RP), Southeastern Brazil, as well as 108 healthy bone marrow donors considered as healthy controls. A total of 108 NMO patients were recruited from five Neurology centers from different Brazilian regions, including Ribeirão Preto (NMO-RP). Principal Findings: European ancestry contribution was higher in MS-RP than in NMO-RP (78.5% vs. 68.7%) patients. In contrast, African ancestry estimates were higher in NMO-RP than in MS-RP (20.5% vs. 12.5%) patients. Moreover, principal component analyses showed that groups of NMO patients from different Brazilian regions were clustered close to the European ancestral population. Conclusions: Our findings demonstrate that European genetic contribution predominates in NMO and MS patients from Brazil.
País: Estados unidos
Unidade acadêmica: Faculdade de Medicina - FM (RG)
Citação: BRUM, Doralina Guimarães Brum et al. European ancestry predominates in neuromielitis optica and multiple sclerosis patients from Brazil. Plos One, San Francisco, v. 8, n. 3, p. e58925, 2013.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1371/journal.pone.0058925
Identificador do documento: 10.1371/journal.pone.0058925
URI: http://repositorio.bc.ufg.br/handle/ri/16909
Data de publicação: Mar-2013
Aparece nas coleções:FM - Artigos publicados em periódicos

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