Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/17038
Tipo do documento: Artigo
Título: Tracing the origin and northward dissemination dynamics of HIV-1 subtype C in Brazil
Autor: Delatorre, Edson Oliveira
Fernandez, José Carlos Couto
Guimarães, Monick Lindenmayer
Cardoso, Ludimila Paula Vaz
Alcantara, Keila Correia de
Stefani, Mariane Martins de Araújo
Romero, Hector
Freire, Caio César de Melo
Iamarino, Atila
Zanotto, Paolo Marinho de Andrade
Morgado, Mariza Gonçalves
Bentancor, Gonzalo José Bello
Abstract: Previous studies indicate that the HIV-1 subtype C epidemic in southern Brazil was initiated by the introduction of a single founder strain probably originating from east Africa. However, the exact country of origin of such a founder strain as well as the origin of the subtype C viruses detected outside the Brazilian southern region remains unknown. HIV-1 subtype C pol sequences isolated in the southern, southeastern and central-western Brazilian regions (n = 209) were compared with a large number (n ~ 2,000) of subtype C pol sequences of African origin. Maximum-likelihood analyses revealed that most HIV-1 subtype C Brazilian sequences branched in a single monophyletic clade (CBR-I), nested within a larger monophyletic lineage characteristic of east Africa. Bayesian analyses indicate that the CBR-I clade most probably originated in Burundi and was introduced into the Paraná state (southern region) around the middle 1970s, after which it rapidly disseminated to neighboring regions. The states of Paraná and Santa Catarina have been the most important hubs of subtype C dissemination, and routine travel and spatial accessibility seems to have been the major driving forces of this process. Five additional introductions of HIV-1 subtype C strains probably originated in eastern (n = 2), southern (n = 2) and central (n = 1) African countries were detected in the Rio de Janeiro state (southeastern region). These results indicate a continuous influx of HIV-1 subtype C strains of African origin into Brazil and also unveil the existence of unrecognized transmission networks linking this country to east Africa.
País: Estados unidos
Unidade acadêmica: Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG)
Citação: DELATORRE, Edson et al . Tracing the origin and northward dissemination dynamics of HIV-1 subtype C in Brazil. Plos One, San Francisco, v. 8, n. 9, e74072, 2013.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1371/journal.pone.0074072
Identificador do documento: 10.1371/journal.pone.0074072
URI: http://repositorio.bc.ufg.br/handle/ri/17038
Data de publicação: 12-Set-2013
Aparece nas coleções:IPTSP - Artigos publicados em periódicos

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