Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/17046
Tipo do documento: Artigo
Título: Gut microbiota, probiotics and diabetes
Autor: Gomes, Aline Corado
Bueno, Allain Amador
Souza, Rávila Graziany Machado de
Mota, João Felipe
Abstract: Diabetes is a condition of multifactorial origin, involving several molecular mechanisms related to the intestinal microbiota for its development. In type 2 diabetes, receptor activation and recognition by microorganisms from the intestinal lumen may trigger inflammatory responses, inducing the phosphorylation of serine residues in insulin receptor substrate-1, reducing insulin sensitivity. In type 1 diabetes, the lowered expression of adhesion proteins within the intestinal epithelium favours a greater immune response that may result in destruction of pancreatic β cells by CD8+ T-lymphocytes, and increased expression of interleukin-17, related to autoimmunity. Research in animal models and humans has hypothesized whether the administration of probiotics may improve the prognosis of diabetes through modulation of gut microbiota. We have shown in this review that a large body of evidence suggests probiotics reduce the inflammatory response and oxidative stress, as well as increase the expression of adhesion proteins within the intestinal epithelium, reducing intestinal permeability. Such effects increase insulin sensitivity and reduce autoimmune response. However, further investigations are required to clarify whether the administration of probiotics can be efficiently used for the prevention and management of diabetes.
Palavras-chave: Probiotics
Insulin resistance
Diabetes mellitus
Inflammation
Gut microbiota
País: Gra-bretanha
Unidade acadêmica: Faculdade de Nutrição - FANUT (RG)
Citação: GOMES, Aline Corado; BUENO, Allain Amador; SOUZA, Rávila Graziany Machado de; MOTA, João Felipe. Gut microbiota, probiotics and diabetes. Nutrition Journal, London, v. 13, n. 60, p. 1-13, 2014.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1186/1475-2891-13-60
Identificador do documento: 10.1186/1475-2891-13-60
URI: http://repositorio.bc.ufg.br/handle/ri/17046
Data de publicação: 2014
Aparece nas coleções:FM - Artigos publicados em periódicos

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