Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/17048
Tipo do documento: Artigo
Título: Supplementing alpha-tocopherol (vitamin E) and vitamin D3 in high fat diet decrease IL-6 production in murine epididymal adipose tissue and 3T3-L1 adipocytes following LPS stimulation
Autor: Lira, Fábio Santos de
Souza, José Carlos Rosa Pires de
Cunha, Claudio Alexandre
Ribeiro, Eliane Beraldi
Nascimento, Claudia Maria da Penha Oller do
Oyama, Lila Missae
Mota, João Felipe
Abstract: Background: It is well known that high fat diets (HFDs) induce obesity and an increase in proinflammatory adipokines. Interleukin-6 (IL-6) is considered the major inflammatory mediator in obesity. Obesity is associated with a vitamin deficiency, especially of vitamins E and D3. We examined the effects of vitamin D3 and vitamin E supplementation on levels of IL-6 and IL-10 (as a marker of anti-inflammatory cytokines since, a balance between pro- and anti-inflammatory cytokines is maintained) protein expression in adipose tissue of mice provided with an HFD. Additionally, we measured the effects of vitamin E and vitamin D3 treatment on LPS-stimulated 3T3-L1 adipocytes IL-6 and IL-10 secretion. Results: IL-6 protein levels and the IL-6/IL-10 ratio were decreased in epididymal white adipose tissue in groups receiving vitamins E and D3 supplementation compared to the HFD group. A 24-hour treatment of vitamin D3 and vitamin E significantly reduced the IL-6 levels in the adipocytes culture medium without affecting IL-10 levels. Conclusions: Vitamin D3 and vitamin E supplementation in an HFD had an anti-inflammatory effect by decreasing IL-6 production in epididymal adipose tissue in mice and in 3T3-L1 adipocytes stimulated with LPS. Our results suggest that vitamin E and D3 supplementation can be used as an adjunctive therapy to reduce the proinflammatory cytokines present in obese patients.
País: Gra-bretanha
Unidade acadêmica: Faculdade de Nutrição - FANUT (RG)
Citação: LIRA, Fábio S. et al. Supplementing alpha-tocopherol (vitamin E) and vitamin D3 in high fat diet decrease IL-6 production in murine epididymal adipose tissue and 3T3-L1 adipocytes following LPS stimulation. Lipids in Health and Disease, London, v. 10, n. 37, p. 1-5, 2011.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1186/1476-511X-10-37
Identificador do documento: 10.1186/1476-511X-10-37
URI: http://repositorio.bc.ufg.br/handle/ri/17048
Data de publicação: 2011
Aparece nas coleções:FM - Artigos publicados em periódicos

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
Artigo - Fábio Santos de Lira - 2011.pdf278,14 kBAdobe PDFThumbnail
Baixar/Abrir


Este item está licenciada sob uma Licença Creative Commons Creative Commons