Sinais e sintomas respiratórios associados ao uso de anti-hipertensivos: uma revisão integrativa
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Data
2015
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Resumo
Objective: To produce a set of information about the respiratory symptoms occasioned by adverse
effects of antihypertensive correlating them with their clinical importance. Methods: Integrative
review developed in a descriptive and observational study, based on the analysis of package inserts
of antihypertensive drugs registered in ANVISA, discussed by scientific articles that evidencing the
clinical application of these effects or the conceptions about the problem. Whereupon the articles
were search on electronic basis, published between 2002 and 2014, in the databases: Cochrane
Library, MEDLINE, Excerpta Medica, LILACS and SciELO. Results: In the 31 drugs of antihypertensive
drug classes covered in the survey, the majority (38.7%) had reactions such as cough and dyspnea as
a common side effect. Other effects such as rhinitis and bronchospasm are present in the use of 29%
of the drugs, but with lower frequency of symptoms (unusual). Being pronounced such events in
inhibiting group angiotensin converting enzyme inhibitors, diuretics subgroups while loop, thiazide
and β-adrenergic antagonists (with the exception of Metoprolol) were far safer for therapy in
patients with respiratory problems. Final consideration: The results presented shows worrying
about the treatment of hypertension, especially when it comes to selection of hypotensive agents in
patients with asthma, Chronic Obstructive Pulmonary Disease or other respiratory conditions. In
addition, the results shows that cough and nasal obstruction, commonly associated with various
diseases, and described as one of the most frequent causes of seeking medical care may be
associated with adverse effects of medication.
Descrição
Palavras-chave
Anti-hipertensivos, Sinais e sintomas, Efeitos Colaterais e reações adversas, Relacionadas a medicamentos, Antihypertensive agents, Signs and symptoms, Drug-related side, Effects and adverse reactions
Citação
BORGES JUNIOR, Orenito Simão; LEMOS, Cristina Ferreira; RABAHI, Marcelo Fouad. Sinais e sintomas respiratórios associados ao uso de antihipertensivos: uma revisão integrativa. RESU: revista educação em saúde, Anápolis, v. 3, n.1, p. 174-192, 2015.