Clinical treatment outcomes of tuberculosis treated with the basic regimen recommended by the Brazilian National Ministry of Health using fixed-dose combination tablets in the greater metropolitan area of Goiânia, Brazil*
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Data
2013
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Resumo
Objective: To describe the rates of cure, treatment failure, and treatment abandonment obtained with the
basic regimen recommended by the Brazilian National Ministry of Health—rifampin, isoniazid, pyrazinamide,
and ethambutol for two months, followed by isoniazid and rifampin for four months—involving the use of
fixed-dose combination tablets (self-administered treatment), as well as to describe adverse events and their
potential impact on treatment outcomes. Methods: This was a descriptive study based on prospective data
obtained from the medical records of tuberculosis patients (≥ 18 years of age) treated with the basic regimen at
either of two primary health care facilities in the greater metropolitan area of Goiânia, Brazil. Results: The study
sample comprised 40 tuberculosis patients. The rate of cure was 67.5%, the rate of treatment abandonment
was 17.5%, and there were no cases of treatment failure. Of the 40 patients in the sample, 19 (47%) reported
adverse reactions, which were mild and moderate, respectively, in 87% and 13% of the cases. It was not necessary
to alter the regimen or discontinue the treatment in any of the cases evaluated. Conclusions: The rate of cure
obtained with the self-administered, fixed-dose combination tablet form of the new basic regimen was similar
to the historical rates of cure obtained with the previous basic regimen. The rate of treatment abandonment
in our sample was much higher than that considered appropriate (up to 5%).
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Palavras-chave
Tuberculosis, Drug combinations, Treatment outcome, Tuberculose, Resultado de tratamento, Combinação de medicamentos
Citação
FERREIRA, Anna Carolina Galvão et al. Desfechos clínicos do tratamento de tuberculose utilizando o esquema básico recomendado pelo Ministério da Saúde do Brasil com comprimidos em dose fixa combinada na região metropolitana de Goiânia. Jornal Brasileiro de Pneumologia, Brasília, v. 39, n. 1, p. 76-83, 2013.