Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/17533
Tipo do documento: Artigo
Título: Comparing intravitreal triamcinolone acetonide and bevacizumab injections for the treatment of diabetic macular oedema: a randomized double- blind study
Autor: Isaac, David Leonardo Cruvinel
Abud, Murilo Batista
Frantz, Kariza Aiko
Rassi, Alan Ricardo
Ávila, Marcos Pereira de
Abstract: Purpose: To compare the effect of a single intravitreal injection of triamcinolone acetonide and bevacizumab in reducing macular thickness, which was measured by optical coherence tomography (OCT) in patients with diabetic macular oedema (DMO). Methods: The patients received a single intravitreal injection of 1.25 mg bev- acizumab in one randomly selected eye and 4.0 mg triamcinolone acetonide in the contralateral eye. Central foveal thickness measurement (CFT) with OCT was taken at the initial visit and at the 4-week, 12-week and 24-week visits. Results: Eleven patients (22 eyes) were enrolled and statistically analysed. CFT reduced in the eyes treated with triamcinolone and those treated with bevacizumab in weeks 4 and 12 (p < 0.05). At the 24-week follow-up, no significant difference was noted, relative to the initial visit. Comparing the two groups treated with dif- ferent drugs, a statistically significant difference in CFT in weeks 4 and 12 was noted, with a more significant reduction in triamcinolone-treated eyes (p < 0.05). Regarding visual acuity (VA), patients treated with triamcinolone had improvement in VA at 4-week (p = 0.02) and 12-week follow-up (p = 0.01), while the group treated with bevacizumab had VA improvement at 4 -week follow-up (p = 0.02). Among the eyes treated with triamcinolone, intraocular pressure (IOP) measure- ment of more than 21 mmHg was found in three eyes (27.3%). Conclusions: Intravitreal triamcinolone proved to be more efficient in reducing DMO, providing longer lasting visual improvement, relative to bevacizumab. Eyes treated with triamcinolone had the highest percentage increase in IOP. Further studies are needed to corroborate these findings.
Palavras-chave: Bevacizumab
Complications from diabetes
Diabetic retinopathy
Visual acuity
Macular oedema ⁄ therapy
Triamcinolone acetonide ⁄ therapeutic use
Triamcinolone acetonide ⁄ administration & dosage
País: Estados unidos
Unidade acadêmica: Faculdade de Medicina - FM (RG)
Citação: ISAAC, David Leonardo Cruvinel et al. Comparing intravitreal triamcinolone acetonide and bevacizumab injections for the treatment of diabetic macular oedema: a randomized double-blind study. Acta Ophthalmologica, Hoboken, v. 90, p. 56-60, 2012.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1111/j.1755-3768.2009.01817.X
Identificador do documento: 10.1111/j.1755-3768.2009.01817.X
URI: http://repositorio.bc.ufg.br/handle/ri/17533
Data de publicação: 2012
Aparece nas coleções:FM - Artigos publicados em periódicos

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