Reproducibility of peripapillary retinal nerve fiber layer thickness measurements using Spectral Domain OCT in Brazilian patients
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Data
2012
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Resumo
Purpose: To evaluate the reproducibility of peripapillary retinal nerve fiber layer
(RNFL) thickness measurements in normal eyes and eyes with glaucoma using
spectral domain optical coherence tomography (SDOCT).
Methods: One eye of 79 normal and 72 glaucoma patients was analyzed. All
patients underwent a complete ophthalmological examination, including visual
acuity testing; intraocular pressure, slit-lamp examination, indirect ophthalmos-
copy; and the glaucoma group underwent achromatic perimetry with the 24-2
SITA Fast Humphrey Field Analyzer. All patients’ eyes were scanned using the
spectral domain optical coherence tomography - Spectralis ® and one of them
was chosen randomly. Three consecutive circular B-scan centered at the optic
disc were performed in one visit.
Results: The intraclass correlation coefficient (ICC), coefficient of variation and
test-retest variability for the mean retinal nerve fiber layer thickness were respec-
tively: 0.94, 2.56% and 4.85 μm for the normal group and 0.93, 4.65% and 6.61 μm
for the glaucomatous group. The intraclass correlation coefficient for retinal nerve
fiber layer thickness in all quadrants were all excellent in both groups, with the
superior quadrant having the highest ICCs (0.964) in glaucomatous eyes and nasal
quadrant measurements having the lowest (0.800), but still excellent in eyes without
glaucoma. The coefficient of variation was between 2.56% - 8.74% and between
4.65% - 11.44% in normal and glaucomatous group respectively. The test-retest
variability was between 4.85 μm and 11.51 μm in the normal group and between
6.61 μm and 14.24 μm in the glaucomatous group. The measurements in glauco-
matous eyes were more variable than normal eyes.
Conclusions: Spectral domain optical coherence tomography showed excellent
reproducibility with regard to retinal nerve fiber layer thickness measurements in
normal and glaucomatous eyes.
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Palavras-chave
Diagnostic techniques, Reproducibility of results, Ophthalmological, Nerve fibers, Glaucoma/diagnosis, Optic nerve/pathology, Tomography, Retinal ganglion cells, Optical coherence/methods, Técnicas de diagnóstico oftalmológico, Reprodutibilidade dos testes, Glaucoma/diagnostico, Tomografia de coerência óptica/métodos, Células ganglionares da retina, Fibras nervosas, Nervo óptico/patologia
Citação
TOSCANO, Daniela Araújo; ÁVILA, Marcos Pereira de; CHALITA, Maria Regina Catai. Reproducibility of peripapillary retinal nerve fiber layer thickness measurements using Spectral Domain OCT in Brazilian patients. Arquivos Brasileiros de Oftalmologia, Rio de Janeiro, v. 75, n. 5, p. 320-323, 2012.