Intravitreal bevacizumab in pigmented rabbit eyes: histological analysis 90 days after injection
Carregando...
Data
2009
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Purpose: To evaluate bevacizumab toxicity in neurosensorial retina and
retinal pigment epithelium in pigmented rabbit eyes by means of histo-
logical studies. Methods: Thirty eyes of fifteen rabbits were distributed
into three groups: sham group (S), that received a 0.1 ml balanced saline
solution (BSS) intravitreal injection (10 eyes); group 1, that received a
1.25 mg (0.1 ml) bevacizumab intravitreal injection (10 eyes); and group
2, that received a 2.5 mg (0.1 ml) bevacizumab intravitreal injection (10
eyes). Rabbits were sacrificed 90 days after the procedure and both eyes
of each rabbit were enucleated. A histological examination of neurosen-
sorial retina and retinal pigmented epithelium (RPE) was performed. Its
morphological features and layer thickness were also analyzed. Results:
No histological differences in neurosensorial retina or in retinal pig-
mented epithelium were found and layer thickness did not differ signi-
ficantly between balanced saline solution-injected eyes and bevacizu-
mab-injected eyes. Conclusion: After a 90-day follow-up period, a single
1.25 or 2.5 mg bevacizumab intravitreal injection did not lead to toxic
damage in the neurosensorial retina and retinal pigment epithelium of
pigmented rabbit eyes, and it appears to be a safe procedure for retinal
neovascular diseases.
Descrição
Palavras-chave
Angiogenesis inhibitors, Models, animal, Macular degeneration, Rabbits, Neovascularization, pathologic, Retina/drug effects, Macula lutea, Injections, Inibidores da angiogênese, Modelos animais, Degeneração macular, Neovascularização patológica, Macula lutea, Retina/efeito de drogas, Injeções, Coelhos
Citação
ARRAES, João Carlos Diniz et al. Intravitreal bevacizumab in pigmented rabbit eyes: histological analysis 90 days after injection. Arquivos Brasileiros de Oftalmologia, São Paulo, v. 72, n. 5, p. 656-660, 2009.