Comparação do efeito analgésico entre etoricoxib 90 mg e dipirona sódica na exérese de pterígio primário com transplante autólogo de conjuntiva
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Data
2009
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Resumo
Purpose: To compare the analgesic effect between dipyrone,
90 mg etoricoxib, and placebo after excision of primary ptery-
gium with conjunctival autograft. Methods: Prospective, ran-
domized, double-masked clinical trial. Three groups of 26 pa-
tients (one eye per patient) were submitted to surgery and re-
ceived the study drugs for five days after surgery. A scale of
pain was used, graduated from zero to ten, for patient evalua-
tion in the first, third and fifth postoperative days. The pain
was classified as absent (zero), mild (1 to 3), moderate (4 to 7)
and severe (8 to 10). Statistical analysis was performed with
the SPSS, version 11.5. Results: A statistically significant dif-
ference was found between etoricoxib and dipyrone in the first
and third postoperative days (p=0.001 and p=0.01; respecti-
vely). Etoricoxib was superior to placebo only in the first pos-
toperative day (p=0.04). There was no significance in the com-
parison between dipyrone and placebo. Conclusions: Anal-
gesia of etoricoxib was superior to placebo in the first pos-
toperative day and to dipyrone in the third and fifth days after
excision of primary pterygium with conjunctival autograft.
There was no significant difference between dipyrone and
placebo in all time points.
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Palavras-chave
Dor pós-operatória, Conjuntiva/transplante, Pterígio, Analgesia, Placebo, Dipirona/uso terapêutico, Piridinas/uso terapêutico, Pain, postoperative, Pterygium, Conjunctiva/transplantation, Placebo, Analgesia, Pyridi- nes/therapeutic use, Dipyrone/therapeutic use
Citação
FRANTZ, Kariza Aiko; MOURA FILHO, Edney de Rezende; ABUD, Murilo Batista; ÁVILA, Marcos Pereira de; MAGACHO, Leopoldo. Comparação do efeito analgésico entre etoricoxib 90 mg e dipirona sódica na exérese de pterígio primário com transplante autólogo de conjuntiva. Arquivos Brasileiros de Oftalmologia, São Paulo, v. 72, n. 5, p. 661-664, 2009.