Análogos das prostaglandinas diminuem a sensibilidade do teste provocativo da ibopamina no glaucoma
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Data
2006
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Resumo
Purpose: To evaluate the ibopamine provocative test for the
diagnosis of glaucoma in glaucoma patients using antiglauco-
matous drugs. Methods: Two 2% ibopamine eyedrops were
instilled 5 minutes apart in one eye selected at random in both
glaucoma and normal subjects. The intraocular pressure (IOP)
was assessed prior to the drops and 30, 60 and 180 minutes
after instillation. The test was considered positive when there
was an intraocular pressure increase of greater than 4 mmHg at
any one of the timepoints. The amount of intraocular pressure
change was compared to the types of medical treatment.
Results: Fifty-eight eyes were included (38 glaucoma patients
and 20 normal individuals). The intraocular pressure rise was significantly higher in glaucoma patients (p<0.001 at all times).
The sensitivity and specificity of the ibopamine test were 68%
(87% if we exclude eyes using prostaglandin analogues) and
95%, respectively. Glaucoma patients using prostaglandin
analogues did not present a significant intraocular pressure
elevation. Conclusion: The ibopamine provocative test may
be an auxiliary test in glaucoma diagnosis. Despite the small
sample size, concurrent use of prostaglandin analogues appa-
rently reduces the test’s sensitivity.
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Palavras-chave
Glaucoma/diagnóstico, Glaucoma/diagnosis, Soluções oftálmicas, Opthalmic solutions, Pressão intra-ocular, Sensibilidade e especificidade, Agonistas de dopamina/uso diagnóstico, Intra-ocular pressure, Dopamine agonists/diagnostic use, Sensitivity and specificity
Citação
MAGACHO, Leopoldo et al. Análogos das prostaglandinas diminuem a sensibilidade do teste provocativo da ibopamina no glaucoma. Arquivos Brasileiros de Oftalmologia, São Paulo, v. 69, n. 2, p. 193-196, 2006.