Use este identificador para citar ou linkar para este item: http://repositorio.bc.ufg.br/handle/ri/17922
Tipo do documento: Artigo
Título: A high-fructose diet induces insulin resistance but not blood pressure changes in normotensive rats
Autor: Bezerra, Rosangela Maria Neves
Silva, Maria Sebastiana
Tavares, Debora Queiroz
Carvalho, C. R. O.
Saad, Mario José Abdalla
Gontijo, Jose Antonio Rocha
Abstract: Rats fed a high-fructose diet represent an animal model for insulin resistance and hypertension. We recently showed that a high-fructose diet containing vegetable oil but a normal sodium/potassium ratio induced mild insulin resistance with decreased insulin receptor sub- strate-1 tyrosine phosphorylation in the liver and muscle of normal rats. In the present study, we examined the mean blood pressure, serum lipid levels and insulin sensitivity by estimating in vivo insulin activity using the 15-min intravenous insulin tolerance test (ITT, 0.5 ml of 6 μg insulin, iv) followed by calculation of the rate constant for plasma glucose disappearance (K itt ) in male Wistar-Hannover rats (110-130 g) randomly divided into four diet groups: control, 1:3 sodium/potas- sium ratio (R Na:K ) diet (C 1:3 R Na:K ); control, 1:1 sodium/potassium ratio diet (CNa 1:1 R Na:K ); high-fructose, 1:3 sodium/potassium ratio diet (F 1:3 R Na:K ), and high-fructose, 1:1 sodium/potassium ratio diet (FNa 1:1 R Na:K ) for 28 days. The change in R Na:K for the control and high-fructose diets had no effect on insulin sensitivity measured by ITT. In contrast, the 1:1 R Na:K increased blood pressure in rats receiv- ing the control and high-fructose diets from 117 ± 3 and 118 ± 3 mmHg to 141 ± 4 and 132 ± 4 mmHg (P<0.05), respectively. Triacylglycerol levels were higher in both groups treated with a high-fructose diet when compared to controls (C 1:3 R Na:K : 1.2 ± 0.1 mmol/l vs F 1:3 R Na:K : 2.3 ± 0.4 mmol/l and CNa 1:1 R Na:K : 1.2 ± 0.2 mmol/l vs FNa 1:1 R Na:K : 2.6 ± 0.4 mmol/l, P<0.05). These data suggest that fructose alone does not induce hyperinsulinemia or hypertension in rats fed a normal R Na:K diet, whereas an elevation of sodium in the diet may contribute to the elevated blood pressure in this animal model.
Palavras-chave: High-fructose diet
Insulin resistance
Blood pressure
Plasma cholesterol
Hypertriglyceridemia
País: Brasil
Unidade acadêmica: Faculdade de Educação Física e Dança - FEFD (RG)
Citação: BEZERRA, R. M. N.; UENO, M.; SILVA, M. S.; TAVARES, D. Q.; CARVALHO, C.R.O.; SAAD, M. J. A.; GONTIJO, J. A. R. A high-fructose diet induces insulin resistance but not blood pressue changes in normotensive rats. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 34, n. 9, p. 1155-1160, 2001.
Tipo de acesso: Acesso Aberto
Identificador do documento: 10.1590/S0100-879X2001000900008
Identificador do documento: 10.1590/S0100-879X2001000900008
URI: http://repositorio.bc.ufg.br/handle/ri/17922
Data de publicação: 2001
Aparece nas coleções:FM - Artigos publicados em periódicos

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